Ayahuasca for Anxiety Disorders

39 papers and 0 clinical trials exploring ayahuasca as a treatment for anxiety disorders.

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
Indication300 million worldwide

Anxiety Disorders

Anxiety disorders, affecting around 300 million people globally, are among the most prevalent mental health conditions. Emerging clinical research suggests that various psychedelics, including psilocybin, MDMA, and LSD, hold potential for alleviating anxiety symptoms through innovative therapeutic approaches.

Full Anxiety Disorders profile

Academic Research

39 papers
Open Accessindividual

Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans

This mixed-methods case series study (n=8) investigated the impact of a 3-day ayahuasca intervention on military veterans with PTSD. Results indicate that 87.5% of participants demonstrated clinically significant improvements in PTSD symptoms post-treatment, with 70% maintaining these changes at a 3-month follow-up. Veterans also reported significant improvements in momentary PTSD symptoms and daily life affect, citing deep positive emotions, decentering/acceptance, and purpose in life as perceived benefits.

Published
Journal
Psychological Trauma
Authors
Beller, N., Campbell, W. K., Dinh-Williams, L., Raugh, I. M., Strauss, G. P., Weiss, B.
Paywallindividual

Ayahuasca Treatment Outcome Project (ATOP): One Year Results from Takiwasi Center and Implications for Psychedelic Science

This naturalistic study (n=52) assessed the one-year post-treatment outcomes of the Takiwasi Centre's ayahuasca-assisted program for addiction rehabilitation in Peru. Using various validated instruments, results showed significant group improvements from baseline to one-year follow-up in alcohol and drug use severity, depression, anxiety, and some quality of life dimensions. While there was individual variation in outcomes and treatment duration, most participants deemed all program aspects, especially the spiritual and therapeutic significance of the ayahuasca experience, as very important.

Published
Journal
Journal of Studies on Alcohol and Drugs
Authors
Garcia, A. M., Loizaga-Velder, A., Marcus, O., Mendive, F., Rush, B., Spitalier, A.
Paywallindividual

Effects of a Single Dose of Ayahuasca in College Students With Harmful Alcohol Use: A Single-blind, Feasibility, Proof-of-Concept Trial

In a single-blind proof-of-concept trial in 11 college students with harmful alcohol use, one dose of ayahuasca with psychological support was well tolerated and produced a short-term reduction in days drinking at 2–3 weeks that did not survive correction for multiple comparisons. The study demonstrates feasibility of the protocol and supports larger, controlled trials to assess efficacy.

Published
Journal
Journal of Clinical Psychopharmacology
Authors
Bouso, J. C., de Lima Osório, F., Dos Santos, R. G., Guerra, L. T. L., Hallak, J. E., Maekawa, R. M., Paranhos, B. A. P. B., Rodrigues, L. S., Rossi, G. N., Santos, F. P., Yonamine, M.
Open Accessindividual

Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects

In a crossover RCT of 31 healthy male volunteers, an ayahuasca‑inspired formulation combining intranasal N,N‑DMT (up to 100 mg) with an orodispersible 100 mg harmine tablet produced robust, phenomenologically rich psychedelic experiences characterised by psychological insights and emotional breakthroughs, low challenging effects, and mainly positive persisting effects at 1 and 4 months. The compound showed good psychological safety and tolerability with no increases in psychopathology or changes in trait measures, indicating potential to support psychotherapeutic applications.

Published
Journal
Frontiers in Psychiatry
Authors
Aicher, H. D., Dornbierer, D. A., Mueller, M. J., Scheidegger, M.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Anxiety Disorders yet.

Trials are continuously being added as new studies are registered.

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