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Home/Research/Ayahuasca/Alcohol Use Disorder (AUD)

Ayahuasca for Alcohol Use Disorder (AUD)

13 papers and 0 clinical trials exploring ayahuasca as a treatment for alcohol use disorder (aud).

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
IndicationOver 100 million cases worldwide, making AUD the most common substance use disorder.

Alcohol Use Disorder (AUD)

Alcohol Use Disorder (AUD) is a prevalent condition characterised by an inability to control alcohol consumption despite adverse consequences. Emerging research indicates that psychedelics may offer promising therapeutic avenues for treating AUD, with various compounds showing potential in clinical trials.

Full Alcohol Use Disorder (AUD) profile

Academic Research

13 papers
Open Accessmeta

Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use

This theory-building article (2023) proposes a model of psychotherapeutic processes associated with ayahuasca consumption. It identifies five key effects: somatic effects, introspection and emotional processing, increased self-connection, increased spiritual connection, and gaining of insights and new perspectives.

Published
January 31, 2023
Journal
Frontiers in Neuroscience
Authors
Perkins, D., Ruffell, S. G. D., day, K., Rubiano, D. P., Sarris, J.
Open Accessmeta

Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies

This systematic review of 27 human and preclinical studies (2000–2021) finds that classic psychedelics—particularly psilocybin—show promising but inconclusive evidence for reducing alcohol consumption. Human studies are hampered by small samples and methodological limitations and preclinical data are scarce and mixed, so higher-quality trials are needed to establish efficacy and mechanisms.

Published
August 31, 2022
Journal
Addiction Biology
Authors
Calleja-Conde, J., Morales-García, J. A., Echeverry-Alzate, V., Bühler, K. M., Giné, E., López-Moreno, J.
Open Accessindividual

Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice

This rodent study (2022) assessed the effects of ayahuasca on the expression of ethanol self-administration using a two-bottle choice test. Treatment with ayahuasca blocked the expression of ethanol self-administration, decreasing ethanol intake and preference during re-exposure tests. Pretreatment with the 5-HT2A receptor antagonist M100907 blocked the effects of ayahuasca on ethanol drinking without significantly attenuating ethanol self-administration.

Published
March 7, 2022
Journal
Psychopharmacology
Authors
Serra, Y. A., Barros-Santos, T., Anjos-Santos, A., Kisaki, N. D., Caio, •., Leite, J. P. C., Santana, M. C. E., Coimbra, J. P. S. A., De Jesus, N. M. S., Sulima, A., Barbo, P. C. R., Malpezzi-Marinho, E. L. A., Rice, K. C., Oliveira-Lima, A. J., Berro, L. F., Marinho, E. A. V.
Open Accessindividual

Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice

This mouse study investigated the effects of ayahuasca (35.2 µg DMT) on alcohol withdrawal in mice and found that it exerted an anxiolytic effect and attenuated the behavioral sensitization to alcohol. Furthermore, it prevented alcohol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin in the striatum.

Published
January 1, 2022
Journal
Behavioural Brain Research
Authors
Almeida, C. A. F., Pereira, B. P., Pereira Junior, A. A., Rangel, J. G., Costa, K. C. M., Bruno, V., Silveira, G. O., Ceron, C. S., Yonamine, M., Camarini, R., Garcia, R. C. T., Marcourakis, T., Torres, L. H.
Paywallindividual

Spiritual experiences in psychedelic-assisted psychotherapy: Case reports of communion with the divine, the departed, and saints in research using psilocybin for the treatment of alcohol dependence

This paper (n=3) presents case studies of experiences with the divine in an ongoing clinical trial at NYU exploring the effects of psilocybin on alcohol dependence.

Published
September 1, 2021
Journal
Spirituality in Clinical Practice
Authors
Podrebarac, S. K., O'donnell, K. C., Mennenga, S. E., Owens, L. T., Malone, T. C., Duane, J. H., Bogenschutz, M. P.
Paywallmeta

Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016-2020) systematic review of preclinical and human studies

This review (2021; s=9) of ayahuasca for substance use disorders (SUDs; e.g. alcoholism) found improvements in both rodents and humans who were suffering from SUDs (also on scores of anxiety and depression). The human studies were observational (vs RCTs) thus lacking the power to (confidently) infer causality.

Published
April 29, 2021
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Osório, F. L., Bouso, J. C., Hallak, J. E., Dos Santos, R. G.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Alcohol Use Disorder (AUD) yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ayahuasca papers Search all Alcohol Use Disorder (AUD) trials Full Ayahuasca profile Full Alcohol Use Disorder (AUD) profile