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Home/Research/Ayahuasca/Borderline Personality Disorder (BPD)

Ayahuasca for Borderline Personality Disorder (BPD)

4 papers and 0 clinical trials exploring ayahuasca as a treatment for borderline personality disorder (bpd).

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
Indication1.8% of adults globally.

Borderline Personality Disorder (BPD)

Research into psychedelic-assisted therapies for Borderline Personality Disorder (BPD) indicates promising potential, particularly with compounds such as ketamine and MDMA, which may enhance emotional processing and neuroplasticity. However, systematic exclusion of BPD patients from psychedelic trials has limited available data, highlighting the need for dedicated research in this area.

Full Borderline Personality Disorder (BPD) profile

Academic Research

4 papers
Open Accessindividual

Ayahuasca in the treatment of bipolar disorder with psychotic features-A retrospective case study

This retrospective case study describes a woman with bipolar disorder and psychotic features whose suicidality, dissociation and social isolation markedly improved and were sustained after multiple ayahuasca ceremonies, with corroboration of childhood abuse and ongoing symptom reduction over several years. The report suggests potential therapeutic benefits of ayahuasca for severe traumatisation and bipolar symptoms and situates the case within a brief review of low‑dose ayahuasca and LSD treatment literature.

Published
March 10, 2023
Journal
Psyarxiv
Authors
Turkia, M.
Open Accessindividual

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

This secondary analysis of a double-blind, parallel-arm, randomised placebo-controlled trial (n=29) investigates the impact of ayahuasca on suicidality (SI) in individuals with treatment-resistant depression (TRD). It found that ayahuasca may show potential as a fast-acting and innovative intervention for SI, but didn't find significant results (only a trend with a large effect size). This is the first study to investigate the use of ayahuasca for SI.

Published
November 19, 2019
Journal
Frontiers in Pharmacology
Authors
Araújo, D. B., Zeifman, R. J., Palhano-Fontes, F., Hallak, J. E., Arcoverde, E., Maia-de-Oliveira, J. P.
Paywallindividual

Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits

This observational study (n=45) suggests that ayahuasca may have a beneficial effect on psychological functioning by improving mindfulness-related capacities. The authors suggest that ayahuasca-assisted therapy could play a role in treating those with borderline personality disorder (BPD) traits.

Published
November 7, 2018
Journal
Psychopharmacology
Authors
Domínguez-Clavé, E., Soler, J., Pascual, J. C., Elices, M., Franquesa, A., Valle, M., Enric Alvarez, &., Riba, J.
Open Accessmeta

Ayahuasca: pharmacology, neuroscience and therapeutic potential

This review (2016) examines the pharmacology and neuroscience of ayahuasca, and preliminary findings which indicate the psychological mechanisms associated with its therapeutic benefits are similar to those of mindfulness-based therapy. Ayahuasca appears to enhance self-acceptance and decentering, which converges on evidence from neuroimaging studies that show activation in areas associated with emotional processing and memory formation, thereby enabling individuals to review emotional events with increased vividness and a heightened sense of “reality”. This suggests potential to treat trauma-related conditions and other disorders like borderline personality disorder.

Published
September 1, 2016
Journal
Brain Research Bulletin
Authors
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., De La Fuente Revenga, M., Friedlander, P., Feilding, A., Riba, J.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Borderline Personality Disorder (BPD) yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ayahuasca papers Search all Borderline Personality Disorder (BPD) trials Full Ayahuasca profile Full Borderline Personality Disorder (BPD) profile