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Home/Research/Ayahuasca/Headache Disorders (Cluster & Migraine)

Ayahuasca for Headache Disorders (Cluster & Migraine)

5 papers and 0 clinical trials exploring ayahuasca as a treatment for headache disorders (cluster & migraine).

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
IndicationOver 3 billion people globally.

Headache Disorders (Cluster & Migraine)

Psychedelics are being researched as potential treatments for headache disorders, including migraines and cluster headaches, which affect a significant portion of the global population. Early findings indicate that psychedelics may modulate pain perception and offer novel therapeutic pathways for those suffering from these debilitating conditions.

Full Headache Disorders (Cluster & Migraine) profile

Academic Research

5 papers
Open Accessindividual

Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD A Randomized Clinical Trial

In a multicentre, double‑blind, placebo‑controlled phase 2 trial of 65 adults with chronic PTSD, once‑weekly oral TSND‑201 produced significantly greater reductions in clinician‑rated PTSD severity (CAPS‑5; LS mean difference 9.64, P = .01) and improvements in self‑reported symptoms, functioning and depression versus placebo. TSND‑201 was generally well tolerated — common adverse events included headache, decreased appetite, nausea, dizziness and transient blood‑pressure increases — supporting its potential as a rapid‑acting, durable treatment for PTSD.

Published
February 18, 2026
Journal
JAMA Psychiatry
Authors
Jones, A., Warner-Schmidt, J., Kwak, H., Stogniew, M., Mandell, B., Ching, T. H., Stein, M. B., Kelmendi, B.
Open Accessindividual

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers

In this open-label exploratory crossover study of nine experienced ayahuasca users, three Acacia‑derived oral formulations delivering DMT plus harmala alkaloids were well tolerated, produced no clinically significant physiological changes, and elicited psychedelic effects rated comparable to (and for ACL‑010 sometimes more beneficial than) traditional ayahuasca. These findings suggest Acacia‑based DMT/harmala formulations are a feasible alternative for future clinical trials, although generalisability is limited by the small sample size and open‑label design.

Published
August 15, 2025
Journal
Frontiers in Psychiatry
Authors
Bonomo, Y. A., Norman, A. F., Collins, L., Ross, M., Dwyer, J., Perkins, D., Sarris, J.
Paywallmeta

Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis

This meta-analysis (s=6) explored the therapeutic effects of psilocybin, LSD and ayahuasca on depressive symptoms in the clinical setting. When administered with psychological support, all psychedelics led to significant reductions in depressive symptoms at all measured timepoints (1-day, 1-week, 3-5 weeks, and 6-8 weeks). Some limitations include the small sample sizes used in most individual studies and the use of a cross-over design for long-term follow-up, which made it difficult to include those results in the meta-analysis.

Published
October 7, 2022
Journal
Journal of Affective Disorders
Authors
Kopra, E., Cleare, A. J., Rucker, J., Ko, K.
Open Accessmeta

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review

This mixed-methods systematic review of 44 clinical studies (598 patients) found serotonergic psychedelics and MDMA to be generally well tolerated but noted that adverse events were poorly defined and likely underreported. Common acute AEs were nausea, headache and anxiety, late AEs included fatigue and low mood, one serious MDMA-related cardiac event occurred, and qualitative data suggest challenging psychological experiences can also have therapeutic value, underlining the need for systematic, detailed AE assessment in future trials.

Published
August 26, 2022
Journal
Journal of Psychopharmacology
Authors
Breeksema, J. J., Kuin, B. W., Kamphuis, J., Van Den Brink, W., Vermetten, E., Schoevers, R. A.
Paywallindividual

Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey

This survey study (n=496) found that indoleamine hallucinogens such as psilocybin and LSD are reportedly comparable to or superior in efficacy against cluster headaches than conventional treatments. Importantly, infrequent and non-hallucinogenic doses of these substances were reported to suffice for this effect to occur.

Published
November 23, 2015
Journal
Journal of Psychoactive Drugs
Authors
Schindler, E. A. D., Gottschalk, C. H., Weil, M. J., Shapiro, R. E., Wright, D. A., Sewell, R. A.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Headache Disorders (Cluster & Migraine) yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ayahuasca papers Search all Headache Disorders (Cluster & Migraine) trials Full Ayahuasca profile Full Headache Disorders (Cluster & Migraine) profile