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Home/Research/Ayahuasca/Medicinal Chemistry & Drug Development

Ayahuasca for Medicinal Chemistry & Drug Development

11 papers and 0 clinical trials exploring ayahuasca as a treatment for medicinal chemistry & drug development.

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
IndicationOver 300 million people worldwide experience depression, with many also suffering from related anxiety disorders.

Medicinal Chemistry & Drug Development

Medicinal chemistry plays a crucial role in the development of novel psychedelic compounds, focusing on their molecular structures and interactions. Researchers utilise innovative methods to enhance safety and efficacy in psychedelic substances.

Full Medicinal Chemistry & Drug Development profile

Academic Research

11 papers
Open Accessindividual

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers

In this open-label exploratory crossover study of nine experienced ayahuasca users, three Acacia‑derived oral formulations delivering DMT plus harmala alkaloids were well tolerated, produced no clinically significant physiological changes, and elicited psychedelic effects rated comparable to (and for ACL‑010 sometimes more beneficial than) traditional ayahuasca. These findings suggest Acacia‑based DMT/harmala formulations are a feasible alternative for future clinical trials, although generalisability is limited by the small sample size and open‑label design.

Published
August 15, 2025
Journal
Frontiers in Psychiatry
Authors
Bonomo, Y. A., Norman, A. F., Collins, L., Ross, M., Dwyer, J., Perkins, D., Sarris, J.
Open Accessindividual

Pharmacokinetics and Pharmacodynamics of an Innovative Psychedelic N,N-Dimethyltryptamine/Harmine Formulation in Healthy Participants: A Randomized Controlled Trial

This secondary analysis of an RCT (n=31) evaluates a novel pharmaceutical formulation of DMT and harmine in healthy male volunteers. The study finds that intranasal DMT and buccal harmine (pharmahuasca) produce consistent pharmacokinetic profiles and safe, well-tolerated effects resembling ayahuasca, with subjective experiences lasting 2-3 hours. This formulation is proposed as a safer, standardised alternative for potential therapeutic use in mental health disorders.

Published
January 8, 2025
Journal
International Journal of Neuropsychopharmacology
Authors
Mueller, J., Mueller, M. J., Aicher, H. D., Dornbierer, D. A., Marten, L., Suay, D., Meling, D., Elsner, C., Wicki, I., Poetzsch, S. N., Caflisch, L., Hempe, A., Steinhart, C., Puchkov, M., Kost, J., Landolt, H-P., Seifritz, E., Quednow, B. B., Scheidegger, M.
Open Accessindividual

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

This open-label within-subject study (n=10) compared the oral administration of a capsule (containing DMT and harmine) with combined intranasal administration of an oromucosal harmine tablet and an intranasal DMT spray at two doses. The research aimed to improve the pharmacokinetics and tolerability profiles of ayahuasca-analogue formulations. Results indicate that the combined buccal/intranasal administration substantially attenuated common side effects and yielded significantly improved pharmacokinetic profiles. This suggests it may be an innovative approach for the safe and patient-oriented administration of DMT/harmine for treating affective disorders.

Published
November 27, 2023
Journal
Frontiers in Pharmacology
Authors
Dornbierer, D. A., Marten, L., Mueller, J., Mueller, M. J., Aicher, H. D., Boxler, M. I., Kometer, M., Kosanic, D., von Rotz, R., Puchkov, M., Kraemer, T., Landolt, H-P., Seifritz, E., Scheidegger, M.
Open Accessmeta

Drug-drug interactions involving classic psychedelics: A systematic review

This systematic review of 52 human studies summarises drug–drug interactions between classic psychedelics (LSD, psilocybin, mescaline, DMT, 5‑MeO‑DMT) and various psychotropic and recreational drugs, finding heterogeneous outcomes — attenuated, potentiated or unchanged effects — with few serious adverse events reported beyond isolated case reports. The paper provides a comprehensive synthesis of clinical evidence and discusses potential molecular mechanisms underlying these interactions.

Published
November 20, 2023
Journal
Journal of Psychopharmacology
Authors
Halman, A., Kong, G., Sarris, J., Perkins, D.
Paywallmeta

Serotonin toxicity of serotonergic psychedelics

This review (2021) evaluates the safety of combining psychedelics and classical serotonin reuptake inhibitors (SSRIs), describes the signs, symptoms, and risk factors of serotonin toxicity, and outlines potential management strategies. They identify the major risk stemming from psychotropics such as ayahuasca that contain monoamine oxidase inhibitors (MAOI) and risk neurotoxicity via the increase intrasynaptic serotonin.

Published
July 12, 2021
Journal
Psychopharmacology
Authors
Malcolm, B., Thomas, K.
Paywallmeta

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies

This systematic review (2020) looked at 10 modern studies (n=188) on psychedelics (psilocybin, ayahuasca, LSD) for the treatment of a variety of mental health disorders. The review found the studies to provide evidence for efficacy (up to months later) and safety.

Published
October 30, 2020
Journal
Acta Psychiatrica Scandinavica
Authors
Andersen, K. A. A., Carhart-Harris, R. L., Nutt, D. J., Erritzoe, D.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Medicinal Chemistry & Drug Development yet.

Trials are continuously being added as new studies are registered.

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