Ayahuasca for Obsessive-Compulsive Disorder (OCD)

2 papers and 0 clinical trials exploring ayahuasca as a treatment for obsessive-compulsive disorder (ocd).

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

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IndicationAbout 1-2% of the population worldwide.

Obsessive-Compulsive Disorder (OCD)

Recent research indicates that psychedelics, particularly psilocybin, are emerging as potential therapeutic agents in the treatment of Obsessive-Compulsive Disorder (OCD). Early clinical trials demonstrate promising results regarding their efficacy and safety, paving the way for future studies in this field.

Full Obsessive-Compulsive Disorder (OCD) profile

Academic Research

2 papers

Open Accessmeta

Default Mode Network Modulation by Psychedelics: A Systematic Review

This systematic review shows that classical psychedelics (LSD, psilocybin, ayahuasca) consistently cause acute disruption of resting-state connectivity within the Default Mode Network and increase cross-network functional connectivity, but it remains unclear how central DMN modulation is to their therapeutic effects. The article synthesises existing evidence and highlights gaps to guide future mechanistic research.

Published: October 22, 2022
Journal: International Journal of Neuropsychopharmacology
Authors: Gattuso, J. J., Perkins, D., Ruffell, S. G. D., Lawrence, A. J., Hoyer, D., Jacobson, L. H., Timmermann, C., Castle, D., Rossell, S. L., Downey, L., Pagni, B. A., Galvão-Coelho, N. L., Nutt, D. J., Sarris, J.

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Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies

This systematic review (2020) looked at 10 modern studies (n=188) on psychedelics (psilocybin, ayahuasca, LSD) for the treatment of a variety of mental health disorders. The review found the studies to provide evidence for efficacy (up to months later) and safety.

Published: October 30, 2020
Journal: Acta Psychiatrica Scandinavica
Authors: Andersen, K. A. A., Carhart-Harris, R. L., Nutt, D. J., Erritzoe, D.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Obsessive-Compulsive Disorder (OCD) yet.

Trials are continuously being added as new studies are registered.

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Search all Ayahuasca papers Search all Obsessive-Compulsive Disorder (OCD) trials Full Ayahuasca profile Full Obsessive-Compulsive Disorder (OCD) profile

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