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Home/Research/Ayahuasca/Personality Disorders

Ayahuasca for Personality Disorders

5 papers and 0 clinical trials exploring ayahuasca as a treatment for personality disorders.

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
IndicationApproximately 9% of adults globally.

Personality Disorders

Personality disorders, characterised by enduring patterns of behaviour, cognition, and inner experience, present substantial challenges in treatment. Emerging research into psychedelics such as psilocybin, MDMA, and ketamine indicates that they may offer novel therapeutic avenues for addressing these complex conditions.

Full Personality Disorders profile

Academic Research

5 papers
Paywallindividual

Examining the Therapeutic Effect of Ceremonial Ayahuasca on Narcissistic Personality and Antagonistic Externalizing in Adults

In a sample of 314 adults, ceremonial ayahuasca use was associated with modest self-reported reductions in some narcissistic antagonism facets (lower entitlement-exploitativeness, higher leadership authority, reduced NPD proxy) lasting up to three months. Effects were small, mixed across measures and not corroborated by informants, indicating no meaningful change and highlighting the need for further targeted research, especially in high-antagonism samples with antagonism-focused therapy.

Published
April 1, 2023
Journal
Journal of Personality Disorders
Authors
Weiss, B., Sleep, C., Miller, J. D., Campbell, W. K.
Open Accessindividual

Ayahuasca in the treatment of bipolar disorder with psychotic features-A retrospective case study

This retrospective case study describes a woman with bipolar disorder and psychotic features whose suicidality, dissociation and social isolation markedly improved and were sustained after multiple ayahuasca ceremonies, with corroboration of childhood abuse and ongoing symptom reduction over several years. The report suggests potential therapeutic benefits of ayahuasca for severe traumatisation and bipolar symptoms and situates the case within a brief review of low‑dose ayahuasca and LSD treatment literature.

Published
March 10, 2023
Journal
Psyarxiv
Authors
Turkia, M.
Open Accessindividual

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

This secondary analysis of a double-blind, parallel-arm, randomised placebo-controlled trial (n=29) investigates the impact of ayahuasca on suicidality (SI) in individuals with treatment-resistant depression (TRD). It found that ayahuasca may show potential as a fast-acting and innovative intervention for SI, but didn't find significant results (only a trend with a large effect size). This is the first study to investigate the use of ayahuasca for SI.

Published
November 19, 2019
Journal
Frontiers in Pharmacology
Authors
Araújo, D. B., Zeifman, R. J., Palhano-Fontes, F., Hallak, J. E., Arcoverde, E., Maia-de-Oliveira, J. P.
Paywallindividual

Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits

This observational study (n=45) suggests that ayahuasca may have a beneficial effect on psychological functioning by improving mindfulness-related capacities. The authors suggest that ayahuasca-assisted therapy could play a role in treating those with borderline personality disorder (BPD) traits.

Published
November 7, 2018
Journal
Psychopharmacology
Authors
Domínguez-Clavé, E., Soler, J., Pascual, J. C., Elices, M., Franquesa, A., Valle, M., Enric Alvarez, &., Riba, J.
Open Accessmeta

Ayahuasca: pharmacology, neuroscience and therapeutic potential

This review (2016) examines the pharmacology and neuroscience of ayahuasca, and preliminary findings which indicate the psychological mechanisms associated with its therapeutic benefits are similar to those of mindfulness-based therapy. Ayahuasca appears to enhance self-acceptance and decentering, which converges on evidence from neuroimaging studies that show activation in areas associated with emotional processing and memory formation, thereby enabling individuals to review emotional events with increased vividness and a heightened sense of “reality”. This suggests potential to treat trauma-related conditions and other disorders like borderline personality disorder.

Published
September 1, 2016
Journal
Brain Research Bulletin
Authors
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., De La Fuente Revenga, M., Friedlander, P., Feilding, A., Riba, J.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Personality Disorders yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ayahuasca papers Search all Personality Disorders trials Full Ayahuasca profile Full Personality Disorders profile