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Home/Research/Ayahuasca/Veterans

Ayahuasca for Veterans

4 papers and 0 clinical trials exploring ayahuasca as a treatment for veterans.

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

Full Ayahuasca profile
Indication~7% of veterans develop PTSD in their lifetime

Veterans

Veterans carry an unusually heavy burden of PTSD, depression, traumatic brain injury, moral injury and suicidality, and many do not respond to standard treatment. That unmet need has put them at the centre of psychedelic research, and of an intense real-world demand. The evidence is genuinely promising but still early and mostly uncontrolled, and in 2024 the US FDA declined to approve MDMA-assisted therapy for PTSD.

Full Veterans profile

Academic Research

4 papers
Open Accessindividual

Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings

Veterans attending naturalistic psilocybin or ayahuasca retreats showed significant improvements across eight mental‑health and reintegration measures, with the largest reductions in depression (PHQ‑9, 29.1%) and PTSD (PCL‑5, 26.1%). Psilocybin retreats produced greater gains on most outcomes while ayahuasca yielded slightly larger PTSD improvement; those with worse baseline symptoms benefited most, with some gender-specific differences.

Published
July 7, 2025
Journal
Brain and Behavior
Authors
Calnan, M., Blest-Hopley, G., Busch, C., Adams, M., Ruffell, S. G. D., Piper, T., Roseman, L., Kettner, H., Carhart-Harris, R.
Open Accessindividual

Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans

This mixed-methods case series study (n=8) investigated the impact of a 3-day ayahuasca intervention on military veterans with PTSD. Results indicate that 87.5% of participants demonstrated clinically significant improvements in PTSD symptoms post-treatment, with 70% maintaining these changes at a 3-month follow-up. Veterans also reported significant improvements in momentary PTSD symptoms and daily life affect, citing deep positive emotions, decentering/acceptance, and purpose in life as perceived benefits.

Published
December 1, 2024
Journal
Psychological Trauma
Authors
Weiss, B., Dinh-Williams, L. A. L., Beller, N., Raugh, I. M., Strauss, G. P., Campbell, W. K.
Open Accessindividual

Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment

Across two cross-sectional studies (n = 54 and n = 306), the authors show that ayahuasca-induced personal death (APD) experiences occur in over half of ceremony participants and are typically intense, transformative events associated with a greater sense of transcending death and certainty in continuity of consciousness. APDs were not linked to demographics, personality or psychopathology but were associated with increased environmental concern and improved coping and life fulfilment, suggesting they may contribute to psychedelics’ long-term beneficial effects.

Published
December 19, 2023
Journal
Frontiers in Psychiatry
Authors
David, J., Bouso, J. C., Kohek, M., Ona, G., Tadmor, N., Arnon, T., Dor-Ziderman, Y., Berkovich-Ohana, A.
Open Accessindividual

Prevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca

Among 339 ayahuasca retreat participants, reexperiencing of adverse life events during ceremonies was common—particularly sexual assault among women, combat trauma among veterans and in those with lifetime PTSD—and was linked to cognitive reappraisal, psychological flexibility and acute discomfort. Those who reexperienced adverse events showed larger reductions in trait neuroticism at follow-up, suggesting such reexperiencing may contribute to the therapeutic effects of ceremonial ayahuasca.

Published
June 9, 2023
Journal
Scientific Reports
Authors
Weiss, B., Wingert, A., Erritzoe, D., Campbell, &. W. K.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Veterans yet.

Trials are continuously being added as new studies are registered.

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Search all Ayahuasca papers Search all Veterans trials Full Ayahuasca profile Full Veterans profile