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Home/Research/DMT/Adolescents

DMT for Adolescents

6 papers and 0 clinical trials exploring dmt as a treatment for adolescents.

CompoundTryptamine

DMT

A powerful, short-acting tryptamine psychedelic found in many botanical sources, known for rapid onset and intense subjective experiences.

Full DMT profile
IndicationApproximately 300 million adolescents worldwide.

Adolescents

Psychedelic use among adolescents presents a complex interplay between cultural context, potential therapeutic benefits, and risks associated with mental health. Recent research suggests that while Western perspectives are largely negative, there is a growing interest in the potential for psychedelics to support mental health treatment in this demographic, particularly in therapeutic settings.

Full Adolescents profile

Academic Research

6 papers
Paywallindividual

Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression

This open-label fixed-order dose-escalation trial (n=14) evaluated inhaled DMT (15mg & 60mg) for treatment-resistant depression (TRD) for the first time. Results showed rapid and sustained antidepressant effects with a 21-point reduction on the Montgomery-Asberg Depression Rating Scale by day 7 (p<0.001), an 86% response rate, and a 57% remission rate lasting up to 3 months, with significant decreases in suicidal ideation (SI).

Published
April 22, 2025
Journal
Neuropsychopharmacology
Authors
Falchi-Carvalho, M., Palhano-Fontes, F., Wießner, I., Barros, H., Bolcont, R., Laborde, S., Silva, S. R. B., Montanini, D., Barbosa, D. C., Teixeira, E., Florence-Vilela, R., Almeida, R., Macedo, R. K. A., Arichelle, F., Pantrigo, E. J., Costa-Macedo, J. V., da Cruz Nunes, J. A., Araújo, D. B., de Araujo Costa Neto, L. A., Nunes Ferreira, L. F., Dantas Correa, L., da Costa Bezerra, R. B., Arcoverde, E., Galvão-Coelho, N. L.
Open Accessindividual

Psilocybin-assisted therapy and HIV-related shame

In a pilot clinical trial (N = 12), psilocybin-assisted group therapy produced a large, statistically significant reduction in HIV-related shame from baseline to three-month follow-up. However, two participants experienced a paradoxical worsening of sexual abuse–related shame, highlighting potential risks for trauma-exposed patients.

Published
August 2, 2024
Journal
Scientific Reports
Authors
Mehtani, N. J., Johnson, M. O., Hendricks, P. S., Mitchell, J., Anderson, B. T.
Open Accessmeta

Drug-drug interactions involving classic psychedelics: A systematic review

This systematic review of 52 human studies summarises drug–drug interactions between classic psychedelics (LSD, psilocybin, mescaline, DMT, 5‑MeO‑DMT) and various psychotropic and recreational drugs, finding heterogeneous outcomes — attenuated, potentiated or unchanged effects — with few serious adverse events reported beyond isolated case reports. The paper provides a comprehensive synthesis of clinical evidence and discusses potential molecular mechanisms underlying these interactions.

Published
November 20, 2023
Journal
Journal of Psychopharmacology
Authors
Halman, A., Kong, G., Sarris, J., Perkins, D.
Open Accessindividual

Ayahuasca in the treatment of bipolar disorder with psychotic features-A retrospective case study

This retrospective case study describes a woman with bipolar disorder and psychotic features whose suicidality, dissociation and social isolation markedly improved and were sustained after multiple ayahuasca ceremonies, with corroboration of childhood abuse and ongoing symptom reduction over several years. The report suggests potential therapeutic benefits of ayahuasca for severe traumatisation and bipolar symptoms and situates the case within a brief review of low‑dose ayahuasca and LSD treatment literature.

Published
March 10, 2023
Journal
Psyarxiv
Authors
Turkia, M.
Paywallindividual

Naturalistic use of psychedelics is related to emotional reactivity and self-consciousness: The mediating role of ego-dissolution and mystical experiences

In a survey of 2,516 participants, greater lifetime naturalistic use of psychedelics predicted higher trait positive and lower negative emotional reactivity, increased reflective/internal self-awareness, and reduced rumination and public self-consciousness. These associations were largely mediated by the intensity of past ego-dissolution and mystical experiences, suggesting such acute experiences underpin long-lasting adaptive changes.

Published
April 27, 2022
Journal
Journal of Psychopharmacology
Authors
Orłowski, P., Ruban, A., Szczypiński, J., Hobot, J., Bielecki, M., Bola, M.
Open Accessmeta

Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder

This review evaluates evidence that serotonergic psychedelics (5‑HT2A agonists such as LSD, psilocybin and DMT) may ameliorate social deficits and co‑occurring anxiety and depression in autism spectrum disorder. It highlights neurobiological constraints (synaptic, serotonergic, prefrontal and thalamocortical dysfunction), mixed and sometimes adverse outcomes in historical paediatric trials, and concludes that rigorous contemporary studies are needed to determine whether benefits outweigh risks and whether 5‑HT2A is a viable therapeutic target.

Published
January 27, 2022
Journal
Frontiers in Pharmacology
Authors
Markopoulos, A., Inserra, A., De Gregorio, D., Gobbi, G.

Clinical Trials

0 trials

No clinical trials have been tagged with both DMT and Adolescents yet.

Trials are continuously being added as new studies are registered.

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Search all DMT papers Search all Adolescents trials Full DMT profile Full Adolescents profile