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Home/Research/DMT/Personality & Trait Factors

DMT for Personality & Trait Factors

9 papers and 0 clinical trials exploring dmt as a treatment for personality & trait factors.

CompoundTryptamine

DMT

A powerful, short-acting tryptamine psychedelic found in many botanical sources, known for rapid onset and intense subjective experiences.

Full DMT profile
IndicationApproximately 10 million adults in the UK suffer from a personality disorder.

Personality & Trait Factors

Psychedelic research is increasingly examining the interplay between personality traits and therapeutic outcomes in various mental health conditions. Recent studies highlight how certain personality traits may influence the efficacy of psychedelic treatments, particularly in managing disorders like depression and anxiety.

Full Personality & Trait Factors profile

Academic Research

9 papers
Open Accessindividual

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers

In this open-label exploratory crossover study of nine experienced ayahuasca users, three Acacia‑derived oral formulations delivering DMT plus harmala alkaloids were well tolerated, produced no clinically significant physiological changes, and elicited psychedelic effects rated comparable to (and for ACL‑010 sometimes more beneficial than) traditional ayahuasca. These findings suggest Acacia‑based DMT/harmala formulations are a feasible alternative for future clinical trials, although generalisability is limited by the small sample size and open‑label design.

Published
August 15, 2025
Journal
Frontiers in Psychiatry
Authors
Bonomo, Y. A., Norman, A. F., Collins, L., Ross, M., Dwyer, J., Perkins, D., Sarris, J.
Open Accessindividual

Population pharmacokinetic-pharmacodynamic modeling of co-administered N,N-dimethyltryptamine and harmine in healthy subjects

This secondary of a single-blind, randomised study (n=16) using DMT (0-120mg) with harmine (0-180mg) in an ayahuasca-inspired (‘pharmahuasca’) formulation found that harmine significantly enhanced DMT bioavailability and prolonged absorption, resulting in higher sustained plasma concentrations and increased subjective psychedelic effects, with population pharmacokinetic/pharmacodynamic modeling revealing substantial interindividual variability in clearance, bioavailability, and sensitivity to psychedelic effects.

Published
August 1, 2025
Journal
Biomedicine & Pharmacotherapy
Authors
Äbelö, A., Smallridge, J. W., Von Rotz, R., Dornbierer, D. A., Egger, K., Ashton, M., Scheidegger, M.
Open Accessindividual

Effects of DMT on mental health outcomes in healthy volunteers

In healthy volunteers, intravenous DMT produced significant reductions in depressive symptoms one to two weeks after administration in both placebo-controlled and prospective samples, with trait neuroticism reduced only in the placebo-controlled group and symptom change correlated with the intensity of acute "oceanic boundlessness" peak experiences. The authors suggest IV DMT’s short, controllable action may alleviate depressive symptomatology via induced peak experiences and warrants further clinical investigation.

Published
February 7, 2024
Journal
Scientific Reports
Authors
Timmermann, C., Zeifman, R. J., Erritzoe, D., Nutt, D. J., Carhart-Harris, R. L.
Open Accessmeta

Sustained effects of single doses of classical psychedelics in humans

This review (2022) explores the acute effects of classic psychedelics in clinical research with humans and summarizes behavioural, biochemical, neuroimaging and electrophysiological data in order to support the notion that the intriguing effects of psychedelics on the human brain and mind are based on neural plasticity.

Published
June 21, 2022
Journal
Neuropsychopharmacology
Authors
Knudsen, G. M.
Paywallindividual

Naturalistic use of psychedelics is related to emotional reactivity and self-consciousness: The mediating role of ego-dissolution and mystical experiences

In a survey of 2,516 participants, greater lifetime naturalistic use of psychedelics predicted higher trait positive and lower negative emotional reactivity, increased reflective/internal self-awareness, and reduced rumination and public self-consciousness. These associations were largely mediated by the intensity of past ego-dissolution and mystical experiences, suggesting such acute experiences underpin long-lasting adaptive changes.

Published
April 27, 2022
Journal
Journal of Psychopharmacology
Authors
Orłowski, P., Ruban, A., Szczypiński, J., Hobot, J., Bielecki, M., Bola, M.
Open Accessindividual

Examining changes in personality following shamanic ceremonial use of ayahuasca

This study of 256 participants across three ayahuasca centres found substantial reductions in Neuroticism after ceremonial ayahuasca use, evident in both self- and informant-reports at post-retreat and three-month follow-up. The degree of personality change was moderated by baseline personality, acute subjective experiences and purgative effects.

Published
March 23, 2021
Journal
Scientific Reports
Authors
Weiss, B., Miller, J. D., Carter, N. T., Campbell, W. K.

Clinical Trials

0 trials

No clinical trials have been tagged with both DMT and Personality & Trait Factors yet.

Trials are continuously being added as new studies are registered.

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Search all DMT papers Search all Personality & Trait Factors trials Full DMT profile Full Personality & Trait Factors profile