DMT for PTSD

4 papers and 0 clinical trials exploring dmt as a treatment for ptsd.

CompoundTryptamine

DMT

A powerful, short-acting tryptamine psychedelic found in many botanical sources, known for rapid onset and intense subjective experiences.

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Indication354 million people suffering from PTSD globally.

PTSD

Posttraumatic stress disorder (PTSD) is a significant mental health challenge affecting over 354 million individuals globally. Psychedelics, particularly MDMA and psilocybin, are emerging as promising therapeutic options, offering new avenues for treatment through innovative psychotherapeutic interventions.

Full PTSD profile

Academic Research

4 papers

Open Accessindividual

5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study

This first longitudinal case study reports that a single inhaled dose of toad‑derived 5‑MeO‑DMT produced rapid, clinically significant and sustained reductions in PTSD symptoms, hopelessness and suicide risk in a 23‑year‑old woman, with the participant endorsing a complete mystical experience and no drug‑related serious adverse events. Improvements persisted to 12 months but were accompanied by acute nausea, overwhelming subjective effects and later night terrors, and the authors emphasise the single‑case design is non‑generalizable and requires controlled replication.

Published: November 23, 2023
Journal: Frontiers in Psychiatry
Authors: August, R. J., Averill, L. A., Barr, N., Barsuglia, J. P., Bass, L. C., Gaffrey, M. S., Jackson, L. K., Kaiyo, M., Khan, R., Ragnhildstveit, A., Seli, P.

Paywallindividual

Posttraumatic Stress Disorder After a Psychedelic Experience, a Case Report

This case report describes a young man who developed posttraumatic stress disorder after an unsupervised psychedelic experience with LSD and DMT during which a repressed childhood sexual‑abuse memory surfaced. As, to the authors' knowledge, the first documented onset of PTSD following psychedelic use outside a therapeutic setting, it emphasises the need for clinicians treating substance‑use disorders or trauma to recognise such atypical presentations.

Published: September 10, 2020
Journal: Journal of Addiction Medicine
Authors: Hassan, A. N., Le Foll, B., Rubin-Kahana, D. S.

Open Accessindividual

Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans

In a retrospective survey of 51 U.S. Special Operations Forces veterans who completed a psychedelic programme in Mexico (ibogaine and 5‑MeO‑DMT), participants reported very large reductions in suicidal ideation, PTSD, depression, anxiety and cognitive impairment alongside large increases in psychological flexibility. These preliminary, self‑reported findings are limited by retrospective design and lack of randomisation/blinding, so controlled trials are needed to establish efficacy.

Published: July 8, 2020
Journal: Chronic Stress
Authors: Amoroso, T., Averill, L. A., Barsuglia, J. P., Davis, A. K., Sepeda, N. D.

Paywallindividual

The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption

In an online survey of 515 respondents, 5‑MeO‑DMT was used infrequently and primarily for spiritual exploration, producing strong self‑reported mystical-type experiences with relatively few challenging effects and low indicators of addiction or adverse legal/medical outcomes. Many users with psychiatric diagnoses reported self‑perceived improvements (e.g. PTSD, depression, anxiety), suggesting potential psychotherapeutic effects that warrant rigorous human safety and pharmacokinetic studies.

Published: April 30, 2018
Journal: Journal of Psychopharmacology
Authors: Barsuglia, J. P., Davis, A. K., Grant, R., Lancelotta, R., Renn, E.

Clinical Trials

0 trials

No clinical trials have been tagged with both DMT and PTSD yet.

Trials are continuously being added as new studies are registered.

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