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Home/Research/Esketamine/Equity and Ethics

Esketamine for Equity and Ethics

2 papers and 0 clinical trials exploring esketamine as a treatment for equity and ethics.

Compounddissociative

Esketamine

Esketamine (Spravato) is the S-enantiomer of ketamine, approved as an intranasal treatment for treatment-resistant depression and MDD with acute suicidal ideation. It is administered under clinical supervision with post-dose monitoring and has reached over $1.6 billion in annual sales.

Full Esketamine profile
IndicationApproximately 1 in 4 adults experience mental health disorders annually worldwide.

Equity and Ethics

Equity and ethics in psychedelic research is a vital and complex topic, addressing the need for fair access and representation in clinical trials, as well as the stewardship of traditional knowledge. The involvement of Indigenous communities, who have historically used these substances, must be safeguarded against exploitation as the field matures.

Full Equity and Ethics profile

Academic Research

2 papers
Paywallmeta

Antisuicidal and antidepressant effects of ketamine and esketamine in patients with baseline suicidality: A systematic review

This review (2021) evaluates the effect of esketamine and ketamine in patients with suicidal ideation at baseline. The authors find that esketamine trials did not demonstrate antisuicidal effects, while IV ketamine appeared to rapidly decrease the short term severity of suicidal ideation and depressive symptoms in individuals with baseline suicidal ideation.

Published
May 1, 2021
Journal
Journal of Psychiatric Research
Authors
Siegel, A. N., Di, J. D., Brietzke, E., Gill, H., Rodrigues, N. B., Lui, L. M. W., Teopiz, K. M., Ng, J., Ho, R., Mcintyre, R. S., Rosenblat, J. D.
Paywallindividual

A rapid positive influence of S-ketamine on the anxiety of patients in palliative care: a retrospective pilot study

A retrospective pilot study of eight palliative care patients given an intravenous S-ketamine infusion (0.25 mg/kg) found a rapid, significant reduction in anxiety compared with matched controls, with no significant change in depression or lasting analgesic effects. Findings are limited by the small, non-randomised retrospective design and need confirmation in prospective randomised trials.

Published
January 3, 2020
Journal
BMC Palliative Care
Authors
Falk, E., Schlieper, D., Van Caster, P., Lutterbeck, M. J., Schwartz, J., Cordes, J., Grau, I., Kienbaum, P., Neukirchen, M.

Clinical Trials

0 trials

No clinical trials have been tagged with both Esketamine and Equity and Ethics yet.

Trials are continuously being added as new studies are registered.

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