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Home/Research/Ibogaine/Adolescents

Ibogaine for Adolescents

2 papers and 0 clinical trials exploring ibogaine as a treatment for adolescents.

CompoundIndole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Full Ibogaine profile
Indication1 in 7 adolescents lives with a mental disorder

Adolescents

Adolescents are a developing-brain, vulnerable population that the modern psychedelic field has mostly studied from the outside: almost all psychedelic trials enrol adults, not minors. The one mature clinical thread in under-18s is ketamine and esketamine for depression and acute suicidality, where benefits are real but modest and often matched by active-placebo arms. For classic psychedelics like psilocybin, LSD and MDMA there is essentially no controlled evidence in adolescents, and the developing brain raises safety questions that adult data cannot answer.

Full Adolescents profile

Academic Research

2 papers
Open Accessindividual

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

In male mice, repeated oral ibogaine (10 or 30 mg/kg) did not produce conditioned place preference but blocked both cue‑ and drug‑induced reinstatement of ethanol‑conditioned place preference in priming‑injection and context‑re‑exposure tests. This indicates ibogaine at non‑rewarding doses may reduce relapse‑like alcohol seeking and warrants consideration as a potential treatment for alcohol use disorder.

Published
September 21, 2021
Journal
Frontiers in Pharmacology
Authors
Henriques, G. M., Anjos-Santos, A., Rodrigues, I. R., Nascimento-Rocha, V., Reis, H. S., Libarino-Santos, M., Barros-Santos, T., Yokoyama, T. S., Bertagna, N. B., Favoretto, C. A., Moraes, C. R., Cruz, F. C., Barbosa, P., Marinho, E. A. V., Oliveira-Lima, A. J., Berro, L. F.
Open Accessindividual

Long-term Follow-Up Outcomes of MDMA-assisted Psychotherapy for Treatment of PTSD: A Longitudinal Pooled Analysis of Six Phase 2 Trials

Pooled analysis of six phase 2 trials found that two to three MDMA‑assisted psychotherapy sessions produced large reductions in PTSD severity at 1–2 months (LS mean change −44.8; Cohen’s d = 1.58) with further small but significant improvement at least 12 months post‑treatment (LS mean change −5.2; d = 0.23). The proportion no longer meeting PTSD criteria rose from 56% at treatment exit to 67% at long‑term follow‑up, most participants reported lasting benefits (improved relationships and well‑being) and only a minority reported harms; phase 3 trials are underway to confirm these results.

Published
June 4, 2020
Journal
Psychopharmacology
Authors
Jerome, L., Feduccia, A. A., Wang, J. B., Hamilton, S., Yazar-Klosinski, B., Emerson, A., Mithoefer, M. C., Doblin, R.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ibogaine and Adolescents yet.

Trials are continuously being added as new studies are registered.

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