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Home/Research/Ibogaine/Chronic Pain

Ibogaine for Chronic Pain

5 papers and 0 clinical trials exploring ibogaine as a treatment for chronic pain.

CompoundIndole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Full Ibogaine profile
IndicationOver 1.5 billion worldwide.

Chronic Pain

Chronic pain is increasingly recognised as a multifaceted condition that may respond to psychedelic therapies, which are gaining attention in clinical settings for their potential efficacy in pain management. Recent research indicates that compounds such as psilocybin and MDMA are entering clinical trials aimed at exploring their therapeutic effects on chronic pain syndromes.

Full Chronic Pain profile

Academic Research

5 papers
Open Accessindividual

Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD A Randomized Clinical Trial

In a multicentre, double‑blind, placebo‑controlled phase 2 trial of 65 adults with chronic PTSD, once‑weekly oral TSND‑201 produced significantly greater reductions in clinician‑rated PTSD severity (CAPS‑5; LS mean difference 9.64, P = .01) and improvements in self‑reported symptoms, functioning and depression versus placebo. TSND‑201 was generally well tolerated — common adverse events included headache, decreased appetite, nausea, dizziness and transient blood‑pressure increases — supporting its potential as a rapid‑acting, durable treatment for PTSD.

Published
February 18, 2026
Journal
JAMA Psychiatry
Authors
Jones, A., Warner-Schmidt, J., Kwak, H., Stogniew, M., Mandell, B., Ching, T. H., Stein, M. B., Kelmendi, B.
Open Accessindividual

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Use

This preprint (2023, v2) animal in vivo and human in vitro study examines a new class of oxa-iboga alkaloids (10 & 40 mg/kg) concerning their effects on opioid addiction in rats and their cardiotoxic effects on human heart cells. In contrast to noribogaine, oxa-iboga analogs exhibited no risk of inducing arrhythmia in adult human primary cardiomyocytes, and oxa-noribogaine induced acute and long-lasting suppression of morphine self-administration in rats in response to both single and repeated dosing regimes.

Published
February 15, 2023
Journal
Biorxiv
Authors
Havel, V., Kruegel, A. C., Bechand, B., Mcintosh, S., Stallings, L., Hodges, A., Wulf, M. G., Nelson, M., Hunkele, A., Ansonoff, M., Pintar, J. E., Hwu, C., Abi-Gerges, N., Zaidi, S. A., Katritch, V., Yang, M., Javitch, J. A., Majumdar, S., Hemby, S. E., Sames, D.
Paywallindividual

Ascending single-dose, double-blind, placebo-controlled safety study of noribogaine in opioid-dependent patients

In a randomized, double‑blind, placebo‑controlled single ascending‑dose study in 27 opioid‑dependent patients, noribogaine was generally well tolerated with dose‑linear pharmacokinetics (t1/2 24–30 h) but caused a concentration‑dependent QTcI prolongation (mean increases ≈16, 28 and 42 ms at 60, 120 and 180 mg) and mostly mild adverse events (visual changes, headache, nausea). There was a non‑significant trend to reduced opioid withdrawal scores, most apparent at 120 mg, but study design limits efficacy conclusions and supports planned exposure‑controlled multiple‑dose trials.

Published
April 1, 2016
Journal
Clinical Pharmacology in Drug Development
Authors
Glue, P., Cape, G., Tunnicliff, D., Lockhart, M., Lam, F., Hung, N., Tak Hung, C., Harland, S., Devane, J., Crockett, R. S., Howes, J., Darpo, B., Zhou, M., Weis, H., Friedhoff, L., Buckland, H.
Open Accessindividual

Noribogaine is a G-Protein Biased κ-Opioid Receptor Agonist

This study examines the specific roles and activities of noribogaine at the opioid receptors in relation to physiological outputs in order to characterize noribogaine to the mu (OPRM) and the kappa (OPRK) opioid receptors. The study observed that the biased agonist/antagonist pharmacology is distinctive to noribogaine in comparison to other ligands including ibogaine, nalmefene, 18-MC, and 6′-GNTI. It predicted that noribogaine promoted some analgesic effects and anti-addictive response.

Published
December 1, 2015
Journal
Neuropharmacology
Authors
Maillet, E. L., Milon, N., Heghinian, M. D., Fishback, J., Schürer, S. C., Garamszegi, N., Mash, D. C.
Open Accessindividual

Effect of Iboga Alkaloids on µ-Opioid Receptor-Coupled G Protein Activation

This in vitro study investigated the molecular mechanism of action of iboga alkaloids, using recombinant mu-opioid receptor-expressing cells, rat thalamic membranes, and rat brain slices. There was no supporting evidence for the hypothesis that opioid withdrawal is mediated by the activation of the mu-opioid receptor.

Published
October 16, 2013
Journal
PLOS ONE
Authors
Antonio, T., Childers, S. R., Rothman, R. B., Dersch, C. M., King, C., Kuehne, M., Bornmann, W. G., Eshleman, A. J., Janowsky, A., Simon, E. R., Reith, M. E. A., Alper, K.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ibogaine and Chronic Pain yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ibogaine papers Search all Chronic Pain trials Full Ibogaine profile Full Chronic Pain profile