Ibogaine for Depressive Disorders

2 papers and 0 clinical trials exploring ibogaine as a treatment for depressive disorders.

CompoundIndole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Full Ibogaine profile

IndicationApproximately 260 million people worldwide are affected by depression.

Depressive Disorders

Depressive disorders, particularly major depressive disorder (MDD), are significant contributors to global mental health issues. Research into the therapeutic potential of psychedelics, such as psilocybin and ketamine, offers promising avenues for treatment, especially for cases that are resistant to conventional therapies.

Full Depressive Disorders profile

Academic Research

2 papers

Open Accessindividual

Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans

In a retrospective survey of 51 U.S. Special Operations Forces veterans who completed a psychedelic programme in Mexico (ibogaine and 5‑MeO‑DMT), participants reported very large reductions in suicidal ideation, PTSD, depression, anxiety and cognitive impairment alongside large increases in psychological flexibility. These preliminary, self‑reported findings are limited by retrospective design and lack of randomisation/blinding, so controlled trials are needed to establish efficacy.

Published: July 8, 2020
Journal: Chronic Stress
Authors: Amoroso, T., Averill, L. A., Barsuglia, J. P., Davis, A. K., Sepeda, N. D.

Open Accessindividual

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

This open-label study (n=14, 8 at follow-up) found that treatment with ibogaine resulted in lower addiction (ASI-Lite) and depression (BDI-II) scores up to 12 months later.

Published: April 12, 2017
Journal: The American Journal of Drug and Alcohol Abuse
Authors: Frampton, C. M., Nollar, G. E., Yazar-Klosinski, B.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ibogaine and Depressive Disorders yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ibogaine papers Search all Depressive Disorders trials Full Ibogaine profile Full Depressive Disorders profile