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Home/Research/Ibogaine/Major Depressive Disorder (MDD)

Ibogaine for Major Depressive Disorder (MDD)

1 paper and 0 clinical trials exploring ibogaine as a treatment for major depressive disorder (mdd).

CompoundIndole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Full Ibogaine profile
IndicationOver 264 million worldwide.

Major Depressive Disorder (MDD)

Major Depressive Disorder (MDD) represents a significant mental health challenge, with emerging research into the efficacy of psychedelics like psilocybin and ketamine offering new avenues for treatment. Recent studies have demonstrated the potential of these compounds to alleviate symptoms, particularly in treatment-resistant cases of MDD.

Full Major Depressive Disorder (MDD) profile

Academic Research

1 paper
Open Accessindividual

Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport

This study investigated serotonin transporter (SERT) complexes with ibogaine to illustrate structure-based mechanisms for transport in serotonin transporter (SERT). The investigation reported that cryo-electron microscopy structures of SERT-ibogaine complexes captured in outward-open, closed and inward-open conformations with ibogaine binding to the central binding site, and the closing extracellular gate with movements of TMs 1b and 6a. The intracellular gate opening had a hinge-like movement of TM1a and the partial unwinding of TM5 that together built a permeation pathway enabling substrate and ion diffusion to the cytoplasm. These structures show the structural rearrangements which occur from the outward-open to inward-open conformations, and give an important insight into the working mechanism of neurotransmitter transport and ibogaine inhibition.

Published
April 24, 2019
Journal
Nature
Authors
Coleman, J. A., Yang, D., Zhao, Z., Wen, P. C., Yoshioka, C., Gouaux, E.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ibogaine and Major Depressive Disorder (MDD) yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Ibogaine papers Search all Major Depressive Disorder (MDD) trials Full Ibogaine profile Full Major Depressive Disorder (MDD) profile