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Home/Research/Ketamine/Fibromyalgia

Ketamine for Fibromyalgia

1 paper and 2 clinical trials exploring ketamine as a treatment for fibromyalgia.

CompoundArylcyclohexylamine

Ketamine

A dissociative anesthetic with rapid-acting antidepressant properties, widely used in clinical settings for mood and pain disorders.

Full Ketamine profile
IndicationApproximately 300 million worldwide are affected by fibromyalgia.

Fibromyalgia

Fibromyalgia is a complex, multifaceted condition affecting individuals through chronic pain and associated symptoms such as depression and anxiety. Emerging research suggests the potential of psychedelics in managing this condition, although robust clinical evidence is still limited.

Full Fibromyalgia profile

Academic Research

1 paper
Open Accessindividual

Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: A randomized, prospective, double blind, active placebo-controlled trial

In a randomised, double-blind, active placebo-controlled trial of 24 fibromyalgia patients, a 30‑minute S‑ketamine infusion produced transient pain reductions that closely tracked plasma levels but yielded no significant long-term analgesic benefit over an eight‑week follow‑up versus midazolam. Side effects were mild–moderate and declined rapidly, suggesting adequate blinding.

Published
January 13, 2012
Journal
European Journal of Pain
Authors
Noppers, I., Niesters, M., Swartjes, M., Bauer, M., Aarts, L., Geleijnse, N., Mooren, R., Dahanl, A., Sarton, E.

Clinical Trials

2 trials
Unknown statusPhase NA

Comparison of Ketamine and Esketamine in Patients Suffering From Fibromyalgia Syndrome

This single-centre, prospective, randomized, double-blind, crossover trial (n=50) aims to compare the efficacy of ketamine and esketamine in ambulatory patients treated for fibromyalgia syndrome in a pain clinic.

Started
July 1, 2021
Type
interventional
Blinding
triple
Randomized
Yes
Registry ID
NCT04938713
Active not recruiting

Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia

This two-part observational trial (n=50) will evaluate the safety and efficacy of intravenous ketamine infusions (1.5–2 mg/kg over 3–4 hours) in reducing pain among patients diagnosed with fibromyalgia.

Started
November 30, 2020
Type
observational
Randomized
No
Registry ID
NCT06916403

Explore further

Search all Ketamine papers Search all Fibromyalgia trials Full Ketamine profile Full Fibromyalgia profile