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Home/Research/Ketamine/Interpersonal Functioning & Social Connectedness

Ketamine for Interpersonal Functioning & Social Connectedness

5 papers and 1 clinical trial exploring ketamine as a treatment for interpersonal functioning & social connectedness.

CompoundArylcyclohexylamine

Ketamine

A dissociative anesthetic with rapid-acting antidepressant properties, widely used in clinical settings for mood and pain disorders.

Full Ketamine profile
IndicationApproximately 300 million individuals worldwide experience issues with social connectedness and interpersonal relations.

Interpersonal Functioning & Social Connectedness

Research on psychedelics highlights their potential to enhance interpersonal functioning and social connectedness, particularly through compounds such as psilocybin and MDMA. These compounds may facilitate therapeutic outcomes in various mental health disorders by fostering emotional connectivity and empathy among individuals.

Full Interpersonal Functioning & Social Connectedness profile

Academic Research

5 papers
Paywallindividual

Entactogen Effects of Ketamine: A Reverse-Translational Study

This randomised, double-blind, placebo-controlled study (n=68) assesses the prosocial, entactogen effects of ketamine (35mg/70kg) in participants with treatment-resistant depression (TRD). Ketamine increased pleasure from social interactions and helping others, lasting for one week post-treatment. In a rodent experiment, ketamine-treated rats showed increased protective behaviour towards their cage mates, indicating entactogen effects.

Published
September 1, 2024
Journal
American Journal of Psychiatry
Authors
Hess, E. M., Greenstein, D. K., Hutchinson, O. L., Zarate, C. A., Gould, T. D.
Open Accessindividual

Trauma Under Psychedelics: MDMA Shows Protective Effects During the Peritraumatic Period

In a naturalistic cohort of 772 survivors of the October 7 Supernova festival attack, participants who were under the influence of MDMA during the trauma reported lower psychological distress, fewer PTSD symptoms, greater social interaction and better sleep in the one to four months post-attack compared with those who were sober, whereas cannabis and/or alcohol use was associated with worse outcomes. These novel findings suggest a putative protective role for MDMA during the peritraumatic period and warrant mechanistic and longitudinal investigation.

Published
March 31, 2024
Journal
Biorxiv
Authors
Netzer, O., Magal, N., Stern, Y., Polinsky, T., Gross, R., Admon, R., Salomon, R.
Paywallmeta

Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis

This meta-analysis assessed the effects of ketamine administration in healthy participants (n=1,041) on several cognitive domains. Deficits in verbal learning/memory were most prominent, whereas response inhibition was the least affected. Negative effects were dependent on infusion dose and plasma level but unaffected by enantiomer type, route of administration, sex or age.

Published
August 1, 2022
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Zhornitsky, S., Pelletier, R., Assaf, R., Potvin, S., Li, C-S., Tourjaman, V.
Open Accessmeta

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

This review summarises preclinical and clinical evidence that ketamine, psilocybin, LSD and MDMA have therapeutic potential for psychiatric disorders — with robust support for ketamine in depression, emerging evidence for psilocybin and LSD in treating depression and modulating functional brain connectivity, and MDMA showing efficacy in PTSD. It also delineates the pharmacology and behavioural effects of psychedelic versus non‑psychedelic hallucinogens and entactogens.

Published
November 30, 2020
Journal
Journal of Neuroscience
Authors
Hibicke, M., Gobbi, G.
Paywallmeta

Efficacy of Psychoactive Drugs for the Treatment of Posttraumatic Stress Disorder: A Systematic Review of MDMA, Ketamine, LSD and Psilocybin

This review (2020, s=9) investigated the therapeutic potential of MDMA, ketamine, LSD, and psilocybin as therapeutic agents for PTSD. However, only studies concerning ketamine and MDMA were found and included in the review, and it is suggested that MDMA-assisted psychotherapy holds moderate promise.

Published
September 15, 2020
Journal
Journal of Psychoactive Drugs
Authors
Varker, T., Watson, L., Gibson, K., Forbes, D.

Clinical Trials

1 trial
CompletedPhase IV

Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers

This randomised controlled trial (n=70) investigated the effects of ketamine on mentalizing and metacognition in healthy volunteers.

Started
June 15, 2019
Type
interventional
Blinding
triple
Randomized
Yes
Registry ID
NCT05320991

Explore further

Search all Ketamine papers Search all Interpersonal Functioning & Social Connectedness trials Full Ketamine profile Full Interpersonal Functioning & Social Connectedness profile