LSD for Personality Disorders

5 papers and 0 clinical trials exploring lsd as a treatment for personality disorders.

Compoundclassic psychedelic

LSD

LSD is a classic psychedelic ergoline with high potency at microgram doses and an 8-12 hour duration of action, mediated primarily via 5-HT2A receptor agonism. Modern Phase IIb data in generalised anxiety disorder and FDA Breakthrough Therapy Designation for MM120 have reignited clinical development.

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IndicationApproximately 9% of adults globally.

Personality Disorders

Personality disorders, characterised by enduring patterns of behaviour, cognition, and inner experience, present substantial challenges in treatment. Emerging research into psychedelics such as psilocybin, MDMA, and ketamine indicates that they may offer novel therapeutic avenues for addressing these complex conditions.

Full Personality Disorders profile

Academic Research

5 papers

Open Accessindividual

Ayahuasca in the treatment of bipolar disorder with psychotic features-A retrospective case study

This retrospective case study describes a woman with bipolar disorder and psychotic features whose suicidality, dissociation and social isolation markedly improved and were sustained after multiple ayahuasca ceremonies, with corroboration of childhood abuse and ongoing symptom reduction over several years. The report suggests potential therapeutic benefits of ayahuasca for severe traumatisation and bipolar symptoms and situates the case within a brief review of low‑dose ayahuasca and LSD treatment literature.

Published: March 10, 2023
Journal: Psyarxiv
Authors: Turkia, M.

Open Accessindividual

Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT-A retrospective case study

This case study (n=1) describes how a teenager self-treated their psychosis (accompanied by complex PTSD and suicidal ideations) through high-dose LSD and low-dose DMT sessions. The hypothesis argues that psychedelics were able to break down the defensive system and allow for the integration of traumatic memories.

Published: December 1, 2022
Journal: Psychiatry Research
Authors: Turkia, M.

Open Accessindividual

Treatment of a Complex Personality Disorder Using Repeated Doses of LSD-A Case Report on Significant Improvements in the Absence of Acute Drug Effects

This case study of a patient with mental health problems, found no acute effects of LSD (50 to 200 µg) and persistent (7 days) positive effects (dose-dependent) on depression (TRD) and suicidal ideation scores.

Published: October 22, 2020
Journal: Frontiers in Psychiatry
Authors: Müller, F., Mühlhauser, M., Holze, F., Lang, U. E., Walter, M., Liechti, M. E., Borgwardt, S.

Open Accessmeta

Acute effects of lysergic acid diethylamide (LSD) on resting brain function

This review of recent fMRI studies finds that acute LSD produces widespread alterations in functional brain connectivity — predominantly increases and most consistently heightened thalamocortical coupling — supporting models of reduced cerebral filtering of external and internal information, though results are tempered by neuroimaging limitations and potential biases.

Published: September 30, 2019
Journal: Swiss Medical Weekly
Authors: Felix, M., Stefan, B.

Open Accessmeta

Ayahuasca: pharmacology, neuroscience and therapeutic potential

This review (2016) examines the pharmacology and neuroscience of ayahuasca, and preliminary findings which indicate the psychological mechanisms associated with its therapeutic benefits are similar to those of mindfulness-based therapy. Ayahuasca appears to enhance self-acceptance and decentering, which converges on evidence from neuroimaging studies that show activation in areas associated with emotional processing and memory formation, thereby enabling individuals to review emotional events with increased vividness and a heightened sense of “reality”. This suggests potential to treat trauma-related conditions and other disorders like borderline personality disorder.

Published: September 1, 2016
Journal: Brain Research Bulletin
Authors: Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., De La Fuente Revenga, M., Friedlander, P., Feilding, A., Riba, J.

Clinical Trials

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No clinical trials have been tagged with both LSD and Personality Disorders yet.

Trials are continuously being added as new studies are registered.

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LSD for Personality Disorders

LSD

Personality Disorders

Academic Research

Ayahuasca in the treatment of bipolar disorder with psychotic features-A retrospective case study

Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT-A retrospective case study

Treatment of a Complex Personality Disorder Using Repeated Doses of LSD-A Case Report on Significant Improvements in the Absence of Acute Drug Effects

Acute effects of lysergic acid diethylamide (LSD) on resting brain function

Ayahuasca: pharmacology, neuroscience and therapeutic potential

Clinical Trials

Explore further