MDMA for Chronic Pain

1 paper and 0 clinical trials exploring mdma as a treatment for chronic pain.

Compoundempathogen

MDMA

MDMA is a synthetic empathogen that enhances monoamine release, producing prosocial and anxiolytic effects without frank hallucinosis. Two Phase III trials demonstrated significant PTSD symptom reductions, though FDA review raised concerns about blinding, durability, and safety characterisation.

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IndicationOver 1.5 billion worldwide.

Chronic Pain

Chronic pain is increasingly recognised as a multifaceted condition that may respond to psychedelic therapies, which are gaining attention in clinical settings for their potential efficacy in pain management. Recent research indicates that compounds such as psilocybin and MDMA are entering clinical trials aimed at exploring their therapeutic effects on chronic pain syndromes.

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Academic Research

1 paper

Open Accessindividual

MDMA-assisted therapy is associated with a reduction in chronic pain among people with post-traumatic stress disorder

In an exploratory analysis of 32 participants from a Phase 2 open‑label trial of manualised MDMA‑assisted therapy for PTSD, 84% reported chronic pain and 75% reported pain‑related disability. MDMA‑AT was associated with significant reductions in pain intensity, disability and overall Chronic Pain Grade Scale severity in the high‑pain subgroup and reduced pain intensity in the medium‑pain subgroup, supporting further investigation of MDMA‑AT for comorbid chronic pain.

Published: November 3, 2022
Journal: Frontiers in Psychiatry
Authors: Argento, E., Christie, D., Kryskow, P., Lessor, D., Nosova, E., Siu, W. O., Yazar-Klosinski, B.

Clinical Trials

0 trials

No clinical trials have been tagged with both MDMA and Chronic Pain yet.

Trials are continuously being added as new studies are registered.

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