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Home/Research/MDMA/Creativity

MDMA for Creativity

4 papers and 0 clinical trials exploring mdma as a treatment for creativity.

Compoundempathogen

MDMA

MDMA is a synthetic empathogen that enhances monoamine release, producing prosocial and anxiolytic effects without frank hallucinosis. Two Phase III trials demonstrated significant PTSD symptom reductions, though FDA review raised concerns about blinding, durability, and safety characterisation.

Full MDMA profile
Indication300 million adults struggling with creative blocks globally.

Creativity

Psychedelics have emerged as potential enhancers of creativity, influencing both divergent and convergent thinking processes. Current research indicates their capacity to disrupt cognitive rigidity and promote innovative thought patterns, warranting further exploration into their therapeutic and recreational applications.

Full Creativity profile

Academic Research

4 papers
Paywallmeta

The risk of chronic psychedelic and MDMA microdosing for valvular heart disease

This review (2023) covers in vitro, animal, and clinical studies to assess the potential risk of valvular heart disease (VHD) from microdosing psychedelic substances, focusing on LSD, psilocybin, mescaline, DMT, and MDMA due to their interaction with the serotonin 5-HT2B receptor. Findings show that all these compounds, except mescaline (due to low potency), were partial agonists at the 5-HT2B receptor. While safety margins from typical microdoses were greater than known valvulopathogens, there remains a potential risk. No studies directly evaluated VHD risk for the four psychedelics, but some evidence suggests chronic ingestion of full doses of MDMA might be linked to VHD.

Published
August 12, 2023
Journal
Journal of Psychopharmacology
Authors
Tagen, M., Mantuani, D., Van Heerden, L., Holstein, A., Klumpers, L. E., Knowles, R.
Open Accessindividual

A Qualitative Study of Intention and Impact of Ayahuasca Use by Westerners

This qualitative study interviewed 41 Western participants about their intentions for, and sustained impacts of, facilitated group ayahuasca experiences. Participants reported a wide range of enduring benefits—including improvements in mental health, substance use, health behaviours, relationships, sense of self, creativity, somatic and physical symptoms, nature connectedness and spirituality—while two participants reported problematic experiences likely related to set and setting; the authors discuss implications for research and practice within a humanistic framework.

Published
April 21, 2021
Journal
Journal of Humanistic Psychology
Authors
Bathje, G. J., Fenton, J., Pillersdorf, D., Hill, L. C.
Open Accessmeta

History and Future of the Multidisciplinary Association for Psychedelic Studies (MAPS)

This review (2014) outlines the historic development of the non-profit association MAPS in its mission to develop medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana. These efforts include the development of psychedelics into prescription medicines, training therapists, establishing treatment centers, supporting scientific research into spirituality, creativity, and neuroscience, and educating the public about the risks and benefits of psychedelic substances. They introduced the first double-blind, placebo-controlled trial of MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD) in 1994 and had planned for FDA prescription approval in 2021. Their ongoing efforts include plans for introducing (LSD)-assisted psychotherapies, parallel to harm-reduction strategies, such as the Zendo Project.

Published
March 11, 2014
Journal
Journal of Psychoactive Drugs
Authors
Emerson, A., Ponté, K. L., Jerome, L., Doblin, R.
Open Accessindividual

Cannabis and Ecstasy/MDMA: Empirical measures of creativity in recreational users

This study compared the creativity levels of 15 recreational MDMA users, 15 cannabis users, and 15 controls. It found higher scores for cannabis users on one scale and self-rating of creativity on another scale for MDMA users. As this was just an observational study, nothing much about the creativity of all three groups can be said.

Published
December 1, 2009
Journal
Journal of Psychoactive Drugs
Authors
Jones, J. A., Blagrove, M., Parrott, A. C.

Clinical Trials

0 trials

No clinical trials have been tagged with both MDMA and Creativity yet.

Trials are continuously being added as new studies are registered.

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