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Home/Research/Psilocybin/Schizophrenia

Psilocybin for Schizophrenia

75 papers and 1 clinical trial exploring psilocybin as a treatment for schizophrenia.

CompoundClassic Psychedelic

Psilocybin

Psilocybin is a naturally occurring tryptamine psychedelic that acts as a prodrug to psilocin, a potent 5-HT2A receptor agonist. It is the furthest advanced psychedelic in clinical development, with two positive Phase III trials in treatment-resistant depression and expanding regulated access in Australia, Germany, and US states.

Full Psilocybin profile
IndicationApproximately 24 million people worldwide are affected by schizophrenia.

Schizophrenia

Schizophrenia is a complex psychiatric disorder characterised by disruptions in thought processes and perception. Recent research into psychedelics has opened new avenues for understanding its neurobiology and exploring potential therapeutic mechanisms, particularly in addressing treatment-resistant symptoms.

Full Schizophrenia profile

Academic Research

75 papers
Open Accessindividual

Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically

This survey (n=581) evaluates the Psychedelic-related Major Life Changes Questionnaire (P-MLCQ) in people reporting naturalistic psychedelic use. It finds that 82.96% of participants reported major life changes in at least one domain, including goals (53.7%), values (53.53%), and spirituality (49.05%), with changes rated highly positively (M = 4.64/5). Frequency of use correlated with more changes (r = 0.34), while education level was negatively associated with the number of changes (β = -0.137).

Published
April 15, 2026
Journal
Scientific Reports
Authors
Aday, J. S., Glynos, N., Baker, A., Pouyan, N., Barron, J., Herberholz, M., Kruger, D. J., Woolley, J. D., Boehnke, K. F.
Paywallindividual

A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive–compulsive disorder

This randomised clinical trial (n=15) found that psilocybin (up to 21mg/70kg) given over up to eight weekly sessions was well-tolerated with no serious adverse events, and significantly reduced OCD symptoms compared to placebo, with 73% of participants responding and 40% reaching remission by the end of the 8-week treatment, with meaningful effects still present at 6 months.

Published
March 13, 2026
Journal
Journal of Psychopharmacology
Authors
Moreno, F. A., Allen, K. E., Wiegand, C. B., Dunne, R., Prickett, J. I., Bayze, B., Allen, J. J. B.
Open Accessindividual

Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis

Qualitative interviews with 12 participants from a randomized, placebo‑controlled single‑dose psilocybin trial for treatment‑refractory OCD showed that set and setting strongly shaped acute (often partial) perceptual, emotional and metacognitive experiences, which were followed by post‑dosing changes in OCD symptoms, perceptions and behavioural/metacognitive processes. These changes mapped onto putative mechanisms of ERP and ACT, suggesting hypotheses for further study and potential value in integrating psilocybin with structured psychotherapy for OCD.

Published
December 10, 2025
Journal
Frontiers in Psychiatry
Authors
Ching, T. H. W., Stahnke, B., Shnayder, S., Agin-Liebes, G., Adams, T. G., Amoroso, L., Baiz, O., Belser, A., Bohner, C., Burke, M., D’Amico, E., DePalmer, G., Eilbott, J., Fram, G., Grazioplene, R., Hokanson, J., Jankovsky, A., Kichuk, S. A., Martins, B., Purohit, P., Schaer, H., Sierra, Y. P., Witherow, C., Pittenger, C., Kelmendi, B.
Open Accessindividual

Psilocybin-assisted psychotherapy for methamphetamine use disorder: A pilot open-label safety and feasibility study

In a single‑arm, open‑label pilot of 15 people with methamphetamine use disorder, outpatient psilocybin‑assisted psychotherapy (single 25 mg oral dose with preparatory and integration sessions) was feasible and well tolerated with no serious adverse events, and was associated with reductions in self‑reported methamphetamine use and craving at 28 and 90 days; a larger randomised trial is required to confirm efficacy and safety.

Published
September 20, 2025
Journal
Addiction
Authors
Knock, E., Siefried, K. J., Gill Bedi, |., Albert, S., Day, R. O., Ezard, N., Ross, M., Liknaitzky, P., Brett, J., Bedi, G.
Open Accessindividual

Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats

This cross-species experimental study (n=21 humans; n=10 rats) finds that psilocin (18.2mg/70kg for humans; 0.3mg/kg for rats) impairs the ability to distinguish between static and moving images in both humans and rats. In humans, the impairment aligns with psilocin plasma levels and self-reported hallucination intensity. In rats, the effect is specific to motion perception, providing the first evidence of psilocin-induced visual distortions across species.

Published
September 1, 2025
Journal
Biological Psychiatry
Authors
Vejmola, C., Šíchová, K., Syrová, K., Janečková, L., Koudelka, V., Tesař, M., Nikolič, M., Viktorin, V., Viktorinová, M., Tylš, F., Korčák, J., Kelemen, E., Nekovářová, T., Brunovský, M., Horáček, J., Kuchař, M., Páleníček, T.
Open Accessindividual

An open-label, dose-escalation trial of psilocybin-assisted therapy for bipolar 2 depression

In an open-label, single-arm dose-escalation pilot (n=14) of psilocybin-assisted therapy for bipolar II depression, psilocybin (10 mg, with 25 mg if needed) was generally well tolerated and produced significant, sustained reductions in depressive symptoms and improved quality of life up to 90 days, with adverse events (including transient anxiety, nausea, headache and three notable psychiatric events) broadly comparable to other psilocybin studies. The authors conclude that randomised, placebo-controlled trials are needed to confirm efficacy and refine dosing protocols in this vulnerable population.

Published
July 7, 2025
Journal
OSF Preprints
Authors
Downey, A. E., Szigeti, B., Bradley, E. R., Fernandes-Osterhold, G., Sakai, K., Llerena, K., Nerayo, J., Fredenburg, L., Nielsen, B., Krystal, A. D., O'donovan, A., Gard, D. E., Woolley, J. D.

Clinical Trials

1 trial
CompletedPhase I/II

Animal and human serotonergic model of schizophrenia: validity evaluated by qEEG and fMRI

Randomised, double‑blind, placebo‑controlled crossover study (n=40) testing a single oral psilocybin dose (18.2 mg/70 kg) versus placebo in healthy volunteers to model psychosis and assess fMRI/qEEG changes.

Started
June 18, 2014
Type
interventional
Blinding
double
Randomized
Yes
Registry ID
2012-004579-37

Explore further

Search all Psilocybin papers Search all Schizophrenia trials Full Psilocybin profile Full Schizophrenia profile