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Shortwave Life Sciences is a UK-listed biopharmaceutical company developing a proprietary psilocybin and beta-carboline buccal film formulation for the treatment of anorexia nervosa. The mucoadhesive film delivery system enables improved bioavailability and rapid onset by bypassing first-pass metabolism, and the company has secured an investigator-initiated Phase 2 clinical trial agreement with Sheba Medical Center in Israel — targeting a condition with no FDA-approved pharmacological treatment.

Development Programmes

1

Psilocybin + Beta-Carboline Buccal Film

Psilocybin
Pre-clinical

Anorexia nervosa

Programme Tracker

Eating Disorders

Primary: Other
Pre-clinicalActive

Preclinical safety completed; Phase 2 investigator-initiated feasibility study approved by Israeli MOH at Sheba Medical Center; preparing for recruitment; buccal film fully developed

Milestones

Company milestone

Completed

Actual: Jul 1, 2022

Clinical trial agreement signed with Sheba Research Fund and Sheba Center for Eating Disorders for investigator-initiated feasibility study

Why it matters: Sheba Medical Center is Israel's largest hospital and a leading eating disorders research center. The investigator-initiated structure means Sheba sponsors the trial while Shortwave provides drug product and retains commercial rights.

Company milestone

Completed

Actual: Jul 1, 2024

PCT patent claims validated for novel mucoadhesive buccal film (novel, non-obvious, industrially applicable)

Why it matters: Patent validation protects the buccal delivery platform. The film combines psilocybin with a beta-carboline (reversible MAO-A inhibitor) to extend psychedelic duration by slowing psilocin metabolism — similar to the ayahuasca mechanism. Buccal delivery also bypasses first-pass metabolism for higher bioavailability.

preclinical-data

Completed

Actual: Sep 1, 2024

Positive preclinical safety results: 3 dose groups in rats with no adverse effects observed

Why it matters: Clean preclinical safety profile supports progression to human dosing in the Sheba feasibility study.

Funding milestone

Completed

Actual: Jul 1, 2025

Raised GBP 290,000 via private and strategic placements (GBP 40K in June + GBP 250K in July 2025)

Why it matters: Very small raise indicates micro-cap status (AQSE-listed as PSY). Sufficient to fund the Israeli feasibility study but not a larger clinical programme.

Company milestone

Completed

Actual: Dec 4, 2025

Dr Nadya Lisovoder presented feasibility study design at PSYCH Symposium

Why it matters: Academic presentation builds credibility and KOL engagement ahead of participant recruitment at Sheba.

Watch next: Feasibility study first patient enrolled; safety and efficacy data from Sheba

Recorded Events

Dec 4, 2025: Company milestone

Jul 1, 2025: Funding milestone

Sep 1, 2024: preclinical-data

Jul 1, 2024: Company milestone

Jul 1, 2022: Company milestone

Quick Facts

Type
Public Biotech
Ticker
AQSE: PSY
Lead Stage
Pre-clinical
Website
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