A Single Ketamine Infusion Combined With Music for Suicidal Ideation

Randomized, factorial, open-label trial (n=200) testing IV ketamine 0.5 mg/kg over 40 minutes and a 60-minute music playlist (Nils Frahm) independently and combined versus treatment as usual in patients presenting with a depressive episode and suicidal ideation.

Primary outcome is reduction in suicidal ideation (SSI) at 4 weeks (response = ≥50% reduction); secondary outcomes include MADRS, SSI over follow-up, adverse events and safety monitoring. Participants monitored in ER/hospital with vitals every 15 minutes during and after infusion; weekly phone follow-up for 4 weeks.