A Study of Different Oral Thin Film (S)-Ketamine Formulations for Sublingual Administration in Healthy Participants

Randomised, four-period crossover in healthy adults to characterise plasma pharmacokinetics of four single-dose sublingual oral thin film (S)-ketamine formulations (OTF 1–4) with at least 72 hours washout between periods.

Primary assessments are PK parameters after each single-dose administration; safety and tolerability monitored via labs and clinical assessment. Key eligibility: BMI 20.0–28.0 kg/m^2, weight 60–100 kg, nonsmokers, females require negative pregnancy tests.