ACT for Alcohol Use Disorder and Depression
This interventional single-group feasibility study (n=20) will assess 8 weekly ACT sessions combined with clinic IV ketamine infusions for adults (18–70) with alcohol use disorder and treatment-resistant depression.
Details
Single-group feasibility study assessing combined Acceptance and Commitment Therapy (8 weekly individual sessions) and clinic-administered IV ketamine infusions in adults with AUD and treatment-resistant depression; primary outcomes are feasibility and preliminary clinical effects on alcohol consumption and depressive symptoms.
Interventions: subanesthetic IV ketamine infusions delivered per CHUM ketamine clinic protocol alongside eight one-hour ACT sessions delivered by trained psychologists. Safety monitoring includes vitals, laboratory tests and standard ketamine clinic precautions.