Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

Single-group, open-label pilot in adults with chronic PTSD receiving a course of six intravenous ketamine infusions (0.5 mg/kg) plus five sessions of Written Exposure Therapy (WET), with WET sessions interleaved with the final two infusions.

Primary outcome is change in PTSD severity (CAPS-5) from baseline to 12 weeks after the start of WET; participants assessed weekly to 12 weeks and monthly up to 24 weeks if improved. The study will also explore whether extinction-learning performance predicts maintenance of ketamine response.