Ayahuasca Assisted Psychotherapy for Grief

Non-randomised, parallel-group trial (n=84) comparing ayahuasca-assisted constructivist therapy, constructivist psychotherapy alone, and no treatment with assessments at baseline, posttest and 3-month follow-up to prevent prolonged or persistent complex bereavement.

Experimental arm receives 9 online psychotherapeutic sessions with one preparation session, two integration sessions and two oral ayahuasca administrations (0.75 mg/kg DMT) after sessions 3 and 6; control arms receive psychotherapy alone or no treatment with option for ayahuasca after follow-up.

Inclusion Criteria:
Experienced the loss of a first-degree relative not more than 12 months prior to enrollment as indicated by self-report.
Scores up to 40 in the Texas Revised Inventory of Grief (TRIG).

Exclusion Criteria:
Pregnant or breastfeeding women.
Hypertension (systolic blood pressure above 140 mm, diastolic above 90 mm and heart rate above 100 bpm).
History of psychotic disorder (Axis I-II of the DSM-V).
Substance use disorder (except nicotine).
Alcohol consumption greater than 40 g/day.
Receiving psychological or self-help therapy during the study on a regular basis.
Receiving regular pharmacological therapy for complicated grief during the study.
Regular intake of any type of medication in the month preceding the study.
Treatment with single doses of symptomatic medication during the study may be accepted (as long as it can be assumed that the ingested drug has been completely eliminated on the days of the ayahuasca administrations).

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Related Publications

Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial

Integration

Therapeutic Protocol

Study Arms & Interventions

Ayahuasca + therapy

Interventions

Constructivist Psychotherapy

Interventions

No treatment

Interventions

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Inclusion Criteria

Exclusion Criteria

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