Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
Observational case-control study (n=60; 30 TRD, 30 healthy controls) assessing EEG and behavioural measures 24 hours after a subanesthetic ketamine injection given as part of clinical care.
Details
This observational case-control study recruits 30 individuals with treatment-resistant major depressive disorder who are already scheduled to receive clinical ketamine treatment and 30 demographically matched healthy controls. Primary assessments include resting-state EEG, cognitive-control tasks, and reward-learning measures performed 24 hours after ketamine administration.
Participants undergo questionnaires, urine drug screening, and electrophysiological recording (EEG); eligibility is confirmed via structured clinical interview and depression scales (IDS-C30, QIDS, HDRS). Healthy controls must have no psychiatric history and no first-degree relative with mood or psychotic disorder.