Bioavailability Study of Psilocybin in Normal Adults

This study compares a single oral 25 mg dose and a single 5 mg intravenous infusion of psilocybin in healthy, screened adults to evaluate pharmacokinetic differences, psychedelic subjective effects and safety.

Each participant receives both routes in separate visits with psychological support; IV dosing is expected to give more consistent blood levels than oral dosing.

Participants are involved for approximately 12 weeks including screening, dosing visits and follow-up assessments.