Biomarkers of Fast Acting Therapies in Major... — Clinical Trial Details

Participants

Ages

18 – 64

Sexes

Male & Female

BMI

Psychosis History

Inclusion Criteria:
Age between 18 to 64 years, inclusive
Diagnosis: DSM-IV TR criteria for non-psychotic major depression
Hamilton Depression Rating Scale-17 item ≥ 18 or Montgomery Asberg Depression Scale ≥ 20
A history of at least one previous major depressive episode prior to the current episode
Recurrent Depression - in the current episode, have not responded to at least 2 adequate antidepressant trials (using Antidepressant Treatment History Form criteria)
Have been continuously depressed for between 6-12 months
Receiving approved monoaminergic antidepressant therapy
No changes in antidepressant medication(s) in the past one (1) month
Voluntary patient receiving ketamine
Capacity to provide informed consent
Have no contraindications to an adjunctive trial of ketamine infusion
Be under the current care of a treating Psychiatrist
If outpatient, a responsible driver available for transportation to and from scanning sessions
Live locally, within travelling distance to UCLA
Be available to participate for a 5-week research follow-up

Exclusion Criteria:
Younger than 18 or older than 64
Serious and imminent suicidal or homicidal risk (active suicidal ideations with or without a plan, HAM-D score ≥ 3 on item 3)
Mental retardation or other developmental disorder
Diagnosis of dementia of any type
History of current substance abuse or dependence
Psychotic reactions to medications, alcohol or illicit substances in the past
Current or past history of psychosis, schizophrenia, bipolar disorder, delusional disorder or other psychotic disorder
Treatment with medications with NMDA and NMDAR action
Contraindication to ketamine
Depression related to serious medical illness (i.e., mood disorder due to general medical condition)
History of neurological disorder or other physical disorder (i.e. significant head injury) that could affect brain functioning
Serious or unstable medical or neurological condition(s) that in the opinion of the treating physician or PI renders ketamine unsafe to administer
Any condition that would contraindicate scanning (metal implants, claustrophobia or a breathing or movement disorder)
Pregnancy (as confirmed by positive urine pregnancy test) or planning on becoming pregnant
Non-English speaking (due to scales administered)
Live outside of the Los Angeles area

Biomarkers of Fast Acting Therapies in Major Depression