Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

This randomised, parallel-group trial will enrol approximately 600 patients already clinically receiving IV ketamine to test whether adjunctive web-based cognitive training versus sham training can enhance or prolong antidepressant response.

Cognitive training consists of self-administered 15–20 minute sessions via a web app delivered during the induction and post-induction phases; primary outcomes include change in depressive symptoms (MADRS) and durability of response.