Combined Ketamine and eCBT Intervention for PTSD

Open-label, non-randomised parallel-group study comparing six sub-anaesthetic IV ketamine infusions combined with a 12-week asynchronous online trauma-focused CBT programme against treatment as usual in participants with refractory PTSD; assessments at baseline, 4, 8 and 12 weeks.

Primary aims are to evaluate clinical efficacy of the combined intervention, explore glutamatergic mechanisms in affective disorders, and assess the utility of pharmacologically-enhanced psychotherapy.