Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD

This prospective, single-group study will enrol 14 adults with PTSD to evaluate clinical and resting-state fMRI connectivity changes associated with Ketamine Assisted Psychotherapy (KAP). Each participant receives two full KAP cycles, each comprising a preparatory session, an intramuscular ketamine administration, and an integration session.

Participants undergo baseline rsfMRI and behavioral assessment, rsfMRI within ~24 hours after each KAP treatment and again ~2 weeks after the second KAP; clinical measures of PTSD symptoms will be correlated with connectivity changes.