Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy
Randomised, double-blind, parallel trial (n=120) comparing two IM ketamine sessions with psychotherapy versus a naturalistic comparator in people with terminal illness; primary outcomes are STAI‑trait and DADDS.
Details
Parallel, randomised, double‑blind study across five sites enrolling 120 participants (90 KAP recipients, 30 naturalistic comparators). KAP recipients receive two IM ketamine sessions (maximum 100 mg per session) spaced 9–15 days apart with preparatory and integration psychotherapy.
Assessments occur across a 4–6 week protocol; primary outcomes are change in STAI (trait) and the Death and Dying Distress Scale (DADDS) from baseline to end of treatment, with safety monitoring throughout.
A six‑subject naturalistic comparator cohort at each site continues usual care and completes the same assessments; comparator participants may optionally cross over to KAP after study completion.