Randomised controlled feasibility trial (n=40) comparing a 21-day meditation-based DIPP versus a music-based DIPP control, each followed by a supervised 25 mg psilocybin session at University College London.
This feasibility randomised trial assigns 40 healthy volunteers 1:1 to either a 21-day digital meditation programme or an active music-listening control. The aim is to evaluate operational feasibility, adherence, and preliminary signals of intervention acceptability.
Following the preparation period, all participants receive a single supervised oral dose of 25 mg psilocybin. Assessments include platform usability and feasibility measures, psychedelic preparedness, acute experience quality, and mental wellbeing at 2 weeks, 3, 6 and 9 months.
Primary outcomes are recruitment/retention and DIPP adherence; secondary outcomes are descriptive implementation metrics and preliminary efficacy measures to inform future trials.
21-day digital meditation-based preparation followed by a supervised 25 mg oral psilocybin session.
25 mg synthetic psilocybin in HPMC capsule (GMP).
21-day music-listening control programme followed by a supervised 25 mg oral psilocybin session.
25 mg synthetic psilocybin in HPMC capsule (GMP).