Does psilocybin alter the brain's response to food choice and reward?

Ten healthy adult participants with prior classic psychedelic experience will undergo an fMRI food-choice task at baseline (~1 week before dosing) and on the day of a single 20 mg oral psilocybin dose to assess acute changes in neural responses to food reward.

During the post-dose scan an in‑scanner gustometer will deliver small (3 ml) low- or high-calorie liquid rewards contingent on choices; onset to scan is ~75 minutes after ingestion and scan duration is ~60 minutes.