This randomised controlled trial (n=45) evaluates a 55-minute psychedelic-like VR intervention (Psyrreal) versus a non-psychedelic VR analogue and a conditional waitlist in adults with clinical depression.
This interventional, randomised, double-blind parallel study uses immersive virtual reality to simulate psychedelic phenomenology (Psyrreal) and compare its effect on depressive symptoms with a non-psychedelic VR analogue (Routine Realms) and a possible waitlist condition.
Each experimental and comparator session is a single 55-minute immersive VR experience embedded in a therapeutic protocol with a preparatory session and a subsequent integration session. The trial will explore clinical outcomes and potential mediators to clarify the role of psychedelic-like subjective experience in treatment response.
Psychedelic virtual reality experience.
55-minute immersive psychedelic VR; part of therapeutic intervention with preparatory and integration sessions.
Non-psychedelic VR analogue.
55-minute non-psychedelic immersive VR; part of therapeutic intervention with preparatory and integration sessions.
Conditional waiting list (may be included subject to resources).
No intervention; conditional waiting list.