Effectiveness of Psychedelic Therapy for Treatment Resistant Depression (TRD)

Open-label, non-randomised interventional service trial delivering psilocybin-assisted psychotherapy for TRD with 2–3 medicine days (usual 25 mg oral psilocybin; optional 10 mg top-up) interleaved with preparatory and integration psychotherapy.

Therapy comprises three 60-minute preparation sessions, a 6–7 hour dosing day with supportive, client-centred psychotherapy, and three 60-minute integration sessions after each dosing day. Sessions may be delivered face-to-face or via Zoom by HREC-approved therapists and the treating psychiatrist; adverse events and psychometrics are recorded.