Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms

This parallel, randomised trial enrolled female patients undergoing gynaecological surgery who scored ≥5 on the Goldberg Depression Screen to assess whether a single low dose of ketamine at induction (0.5 mg/kg IV) reduces depressive symptoms after surgery.

All participants received routine premedication (midazolam and fentanyl); outcomes included Goldberg Depression Screen at baseline and at one week, and monitoring for adverse events including suicidal ideation, nausea and vomiting.