Randomised, double-blind, parallel study (n=12) testing a single 0.5 mg/kg IV ketamine dose at induction of anaesthesia versus no ketamine in female surgical patients with depressive symptoms.
This parallel, randomised trial enrolled female patients undergoing gynaecological surgery who scored ≥5 on the Goldberg Depression Screen to assess whether a single low dose of ketamine at induction (0.5 mg/kg IV) reduces depressive symptoms after surgery.
All participants received routine premedication (midazolam and fentanyl); outcomes included Goldberg Depression Screen at baseline and at one week, and monitoring for adverse events including suicidal ideation, nausea and vomiting.
Ketamine 0.5 mg/kg IV at induction of general anesthesia.
Given at induction alongside midazolam and fentanyl per anaesthetic care.
Standard induction without ketamine.