Randomised, quadruple-blind, placebo-controlled crossover study (n=45) testing single oral high (100 µg) versus low dose LSD in healthy volunteers to assess effects on neuroplasticity.
LSD is a potent psychoplastogen shown to rapidly stimulate neuroplasticity in animal models, but direct evidence in humans is limited. This study investigates whether single doses of LSD enhance measures of cortical plasticity and related cognitive and emotional traits in healthy adults.
The trial uses a randomised, quadruple-blind, placebo-controlled crossover design comparing a high single oral dose (100 µg) and a low single oral dose; outcomes include neurophysiological and neuroimaging measures of plasticity, and behavioural and self-report assessments over follow-up.
Healthy volunteers aged 21–55 are enrolled at the University of Fribourg; the registry reports an actual enrolment of 45 participants.
High single oral dose of LSD; crossover vs low dose.
100 µg LSD base; single dosing session.
Low single oral dose of LSD; active comparator in crossover.
Low dose of LSD base (dose not specified in registry fragment).