Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators
Double-blind, placebo-controlled study (n=40) using single or repeated all-day oral psilocybin sessions to examine acute and persisting effects on meditation, spirituality, well-being, prosocial attitudes and brain function in long-term meditators.
Details
Randomized, double-blind, parallel-design study in long-term meditators comparing moderately-high oral psilocybin to placebo across arms with one, two or three all-day sessions; an optional MRI arm examines acute effects with very-low or moderately-low doses.
Primary measures include questionnaires on meditation, spirituality, well-being and prosocial attitudes, and functional MRI to assess brain function; procedures include screening, preparatory meetings (approximately 8 hours), supervised dosing sessions, and follow-ups at 1 day, 2 months and 12–18 months.
Safety screening excludes participants with major medical or psychiatric conditions, recent substance dependence, or family history of psychosis; women of child-bearing potential must use effective contraception.