Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

This randomised, two-period crossover Phase II trial evaluates single intravenous ketamine infusions (0.5 mg/kg and 0.2 mg/kg) in participants with postpartum depression with a 7-day washout between sessions.

Primary objectives are safety and pharmacokinetics; antidepressant efficacy is assessed using standard rating scales (EPDS, HAM-D) with eligibility requiring moderate to severe symptoms and stability of concomitant antidepressant treatment.