Evaluation of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military Veterans

This single-group, Phase II study will recruit eight military veterans with PTSD to evaluate acceptability, feasibility, safety and preliminary efficacy of psilocybin-assisted psychotherapy (PaP).

Intervention: two oral 25 mg psilocybin dosing sessions (8-hour sessions) with two preparatory sessions and 12 sessions of Cognitive Processing Therapy; primary outcome changes in PCL-5 from baseline to one-month follow-up.