Evaluation of Psilocybin (TRP-8802) to Decrease... — Clinical Trial Details

Single-centre, open-label Phase IIa study of TRP-8802 (psilocybin) in adults with binge eating disorder to assess safety and feasibility with a single 25 mg oral dose paired with preparatory and integration psychotherapy.

Participants undergo screening, preparatory therapy (6–8 hours), a monitored dosing session, and integration plus follow-up to 12 weeks post-dose (Week 14); total participation approximately 5 months.

Participants

Ages

18 – 64

Sexes

Male & Female

BMI

Psychosis History

Excluded

Inclusion Criteria

To participate in this study, subjects will have to meet all of the following criteria:
1. Meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for BED.
2. Age ≥18 and ≤64 years.
3. Provision of signed and dated informed consent form.
4. Stated willingness to comply with all study procedures and availability for the duration of the study.
5. Medically stable in the judgment of the Principal Investigator, as determined by screening medical, physical examination, ECG, and routine laboratory tests including blood and urinalysis.
6. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 4 weeks following the dose of TRP 8802. Adequate birth control methods include intrauterine device; injected, implanted, intravaginal, or transdermal hormonal method; oral hormones plus a barrier contraception; abstinence; vasectomized sole partner; or double barrier contraception.
7. For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner through 90 days post-dose.
8. Agree to consume approximately the same amount of caffeine-containing beverage (e.g., coffee, tea) that he/she consumes on a usual morning, before arriving at the research unit on the morning of the drug session day. If the participant does not routinely consume caffeinated beverages, he/she must agree not to do so on the dosing session day.
9. Agree to refrain from using any psychoactive drugs, including alcoholic beverages for a minimum of 1 week prior to drug administration.
10. Agree that for 1 week before the drug session, including the morning of the session, he/she will refrain from taking any nonprescription medication, nutritional supplement, herbal supplement, or as needed (PRN) prescription medication except when approved by the study investigators. Exceptions will be evaluated by the study investigators and will include acetaminophen, non-steroidal anti-inflammatory drugs, and common doses of vitamins and minerals and contraceptives.

Exclusion Criteria

To participate in this study, subjects must not meet any of the following criteria:
1. Significant suicide risk as defined by either suicidal ideation as endorsed on items 4 or 5 on the C-SSRS within the past year, at Screening, or at Baseline; or suicidal behaviors within the past year; clinical assessment of significant suicidal risk during subject interview.
2. Participation in another concurrent clinical study or within the preceding month.
3. Women who are pregnant or who intend to become pregnant during the study or who are currently nursing.
4. Vital signs, averaged over 3 readings within 15 minutes, of systolic blood pressure (BP) >139 mm Hg, diastolic BP >89 mm Hg, or heart rate >90 bpm.
5. Have any of the following cardiovascular conditions: uncontrolled hypertension, coronary artery disease, congenital long QT syndrome, cardiac hypertrophy, cardiac ischemia, congestive heart failure, prior myocardial infarction, tachycardia, artificial heart valve, QTc >450 msec at screening, any other clinically significant screening ECG abnormality, or any other significant cardiovascular condition.
6. Presence of a gastrointestinal disease that could interfere with absorption of orally-administered TRP 8802.
7. Have epilepsy.
8. Meet DSM-5 criteria for schizophrenia spectrum or other psychotic disorders, including major depressive disorder with psychotic features, or Bipolar I or Bipolar II Disorder.
9. Family history of psychosis.
10. Meet DSM-5 criteria for a moderate or severe alcohol or drug use disorder.
11. Positive urine drug screen or alcohol breath test at screening. A repeat test can be conducted at screening or Day -1 at the discretion of the Principal Investigator or delegate.
12. Prior adverse effects from psilocybin.
13. Currently taking or expected to need prior to the dosing session, UGT1A9 or 1A10 inhibitors (e.g., regorafenib, rifampicin, phenytoin, eltrombopag, mefenamic acid, diflunisal, niflumic acid, sorafenib, isavuconazole, deferasirox, ginseng) and aldehyde or alcohol dehydrogenase inhibitor (e.g., disulfiram).
14. Currently taking or testing positive on urine drug screen, drugs of abuse such as amphetamines, buprenorphine, benzodiazepines, cocaine, methamphetamines, Ecstasy (MDMA), morphine, methadone, oxycodone, marijuana, ethyl glucuronide, fentanyl, tramadol, and synthetic cannabinoids (K2).

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Evaluation of Psilocybin (TRP-8802) to Decrease Hyperphagia

Detailed Description

Study Protocol

Preparation

Dosing

Locations

Related Publications

An open-label pilot study of psilocybin-assisted therapy for binge eating disorder

Integration

Therapeutic Protocol

Study Arms & Interventions

Open Label Oral Psilocybin

Interventions

Participants

Inclusion Criteria

Exclusion Criteria

Study Details

Study Team

Sponsors & Collaborators