Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients with Psychogenic Nonepileptic Seizures (CRIPSY)

This single-group treatment study will administer a single 25 mg oral dose of psilocybin to patients with video‑EEG‑confirmed PNES and assess neural correlates of cognitive control using MRI and fMRI before (D-3) and after (D5) treatment.

Rationale: dysregulation of frontal and default mode network regions may underlie impaired cognitive control in PNES; the trial tests whether psilocybin modulates these neural networks and associated cognitive control measures.