This interventional trial (n=50) conducted by the University of Kansas Medical Center will assess the feasibility and safety of administering a single dose of ketamine to acutely suicidal patients in the Emergency Department.
Phase I single-group study to evaluate safety and feasibility of a single low-dose IV ketamine (0.2 mg/kg) given to acutely suicidal ED patients; primary outcomes are safety and feasibility metrics.
Participants are observed in the ED for 2 hours post-dose, then transferred for inpatient psychiatric care; depressive and suicidal symptoms are assessed at 0, 2 hours, 24 hours and 72 hours alongside ED staff feasibility surveys.
Single low-dose IV ketamine (0.2 mg/kg) administered in the ED to acutely suicidal patients; single-group feasibility/safety design.
Observed in ED for 2 hours then transferred to psychiatric admission as per standard care; assessments at 0, 2h, 24h, 72h.