Food Effects on Bioavailability of MDMA in Healthy Volunteers (MPKF)

Randomized sequence, two-period crossover comparing fasted (≥10 h) and fed (high‑fat, 800–1000 kcal) conditions; each period includes a single oral dose of MDMA (100 mg midomafetamine, ≈120 mg HCl equivalent).

Participants are confined at the clinical research unit from check-in the night before dosing until at least 48 hours after dosing for PK sampling (0–72 h) and safety monitoring; an additional outpatient visit at 72 hours collects final PK and safety assessments.