Open, observational study (Archives of General Psychiatry, March 1962; Freedman AM, Ebin EV, Wilson EA) at a day school for children with schizophrenia. From a total school population of 40, 12 well-known pupils were selected who met the authors' criteria for autistic schizophrenia: 10 boys and 2 girls aged 5 years 11 months to 11 years 10 months; 7 were essentially mute and the other 5 used words or phrases only occasionally. No control arm or randomisation. Intervention: d-lysergic acid diethylamide (LSD-25) administered in an open exploratory design; dose details and session structure not fully described in available methods extract. Outcomes: behavioural and developmental observations at the day school. No trial registry; pre-dates any formal registration requirement.
This synthetic trial has been added to our database because a psychedelic paper (about a clinical trial) references this trial, but no (live) registration can be found.
The study involved twelve children, aged approximately six to twelve years, attending a day school for schizophrenic children. The participants were primarily mute or minimally verbal, and the researchers employed an open exploratory design to observe the effects of oral LSD-25 administration.
Doses ranging from 50µg to 200µg were administered in various vehicles such as juice or soft drinks. While researchers observed various somatic and psychic effects, including mood fluctuations and hallucinations, the primary objective of transitioning children from muteness to speech was not achieved.
Oral administration of LSD-25 in a vehicle (e.g., chocolate milk, coffee, orange juice, Coca Cola, cocoa, milk, water) to autistic schizophrenic children.
Standard dose for most patients; administered in a preferred vehicle.
Administered to one smaller girl.
Administered to one boy on a second occasion (initial dose was 100µg).
Administered on one occasion.