Investigating the impact of Psilocybin and guided meditation on brain connectivity in healthy adults
Phase I interventional study (n=60) testing a single oral psilocybin 19 mg dose with vs without an 8‑week guided meditation programme to assess effects on brain connectivity (fMRI & EEG) in healthy adults.
Details
Sixty healthy volunteers undergo baseline and dosing‑day fMRI (≈60 min) and EEG (≈90 min) with naturalistic visual stimuli, music and guided open‑awareness meditation to measure changes in brain directed connectivity.
Half the participants receive 8 weekly 60‑minute meditation training (mindfulness, focused attention, open awareness, self‑compassion) with daily practice; adherence measured by FFMQ, MAQ, MEDI, EQ, SCS and weekly reflection questionnaires.
Primary outcomes are changes in effective (directed) brain connectivity measured across subjects and between groups using resting‑state fMRI and EEG at baseline and on the day of dosing.